A Distinct "Side Population" of Cells with High Drug Efflux Capacity in Human Tumor Cells

A subset of stem cells, termed the "side population" (SP), has been identified in several tissues in mammalian species. These cells maintain a high efflux capability for antimitotic drugs. We have investigated whether functionally equivalent stem cells also may be detected in human cancers...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-09, Vol.101 (39), p.14228-14233
Hauptverfasser:	Hirschmann-Jax, C., Foster, A. E., Wulf, G. G., Nuchtern, J. G., Jax, T. W., Gobel, U., Goodell, M. A., Brenner, M. K., Prockop, Darwin J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, Surface - analysis Antineoplastic Agents - pharmacology ATP-Binding Cassette Transporters - biosynthesis Benzimidazoles - pharmacokinetics Biological Sciences Cell Line, Tumor Cell lines Cell Survival Child Child, Preschool Cultured cells Drug Resistance, Neoplasm Drug therapy Dyes Female Flow Cytometry Fluorescent Dyes - pharmacokinetics Gene Expression Humans Infant Male Medical research Middle Aged Mitoxantrone - pharmacology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Neuroblastoma Neuroblastoma - drug therapy Neuroblastoma - metabolism Neuroblastoma - pathology Neurons Proto-Oncogene Proteins c-kit - biosynthesis Relapse Stem cells Tumor cell line Tumor stem cells Tumors
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