The portal‐drained viscera release fibroblast growth factor 19 in humans

Fibroblast growth factor 19 (FGF19) is an ileum‐derived endrocrine factor that is produced in response to transepithelial bile salt flux. FGF19 represses bile salt synthesis in the liver. Despite the general assumption that FGF19 signals to the liver via portal blood, no human data are available to...

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Veröffentlicht in:	Physiological reports 2016-12, Vol.4 (24), p.np-n/a
Hauptverfasser:	Koelfat, Kiran V. K., Bloemen, Johanne G., Jansen, Peter L. M., Dejong, Cornelis H. C., Schaap, Frank G., Olde Damink, Steven W. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Bile Bile Acids and Salts - blood Bile salts Blood Digestive Conditions, Disorders and Treatments entero‐hepatic circulation Female FGF19 Fibroblast growth factors Fibroblast Growth Factors - blood Fibroblasts Growth factors Humans Ileum Liver Male Metastases Middle Aged organ fluxes Original Research Patients Physiology Portal System - metabolism Regulatory Pathways Salt Salts Surgery Veins & arteries Viscera Viscera - blood supply Viscera - metabolism
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