Internal jugular pressure increases during parabolic flight
One hypothesized contributor to vision changes experienced by >75% of International Space Station astronauts is elevated intracranial pressure (ICP). While no definitive data yet exist, elevated ICP might be secondary to the microgravity‐induced cephalad fluid shift, resulting in venous congestio...
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| description | One hypothesized contributor to vision changes experienced by >75% of International Space Station astronauts is elevated intracranial pressure (ICP). While no definitive data yet exist, elevated ICP might be secondary to the microgravity‐induced cephalad fluid shift, resulting in venous congestion (overfilling and distension) and inhibition of cerebrospinal and lymphatic fluid drainage from the skull. The objective of this study was to measure internal jugular venous pressure (IJVP) during normo‐ and hypo‐gravity as an index of venous congestion. IJVP was measured noninvasively using compression sonography at rest during end‐expiration in 11 normal, healthy subjects (3 M, 8 F) during normal gravity (1G; supine) and weightlessness (0G; seated) produced by parabolic flight. IJVP also was measured in two subjects during parabolas approximating Lunar (1/6G) and Martian gravity (1/3G). Finally, IJVP was measured during increased intrathoracic pressure produced using controlled Valsalva maneuvers. IJVP was higher in 0G than 1G (23.9 ± 5.6 vs. 9.9 ± 5.1 mmHg, mean ± SD P |
| doi_str_mv | 10.14814/phy2.13068 |
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Internal jugular venous pressure (IJVP) was evaluated noninvasively before, and during reduced gravity in parabolic flight. While in microgravity, IJVP was higher in all 11 subjects (23.9 ± 5.6 vs. 9.9 ± 5.1 mmHg, P < 0.001).</description><identifier>ISSN: 2051-817X</identifier><identifier>EISSN: 2051-817X</identifier><identifier>DOI: 10.14814/phy2.13068</identifier><identifier>PMID: 28039409</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Adult ; Astronauts ; Blood Pressure ; Catheters ; Compression ; Compression therapy ; Distension ; Female ; Gravitation ; Gravity ; Humans ; Hypogravity ; Hypotheses ; Jugular Veins - physiology ; Laboratories ; Male ; Microgravity ; Middle Aged ; Neurological Conditions, Disorders and Treatments ; Original Research ; Participation ; Physiology ; Pressure ; Respiration ; Sensory Neuroscience ; Space Flight ; Spaceflight ; Ultrasonic imaging ; Veins & arteries ; Venous Pressure ; Visual impairment ; visual impairment and intracranial pressure ; Weightlessness ; Weightlessness Simulation</subject><ispartof>Physiological reports, 2016-12, Vol.4 (24), p.np-n/a</ispartof><rights>Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society</rights><rights>Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.</rights><rights>2016. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5138-dee14b3afd6d4372621da6c488d82d8a1e3dc4524eaadbeab603771c497e5ebe3</citedby><cites>FETCH-LOGICAL-c5138-dee14b3afd6d4372621da6c488d82d8a1e3dc4524eaadbeab603771c497e5ebe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210371/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210371/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,1414,11549,27911,27912,45561,45562,46039,46463,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28039409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martin, David S.</creatorcontrib><creatorcontrib>Lee, Stuart M. C.</creatorcontrib><creatorcontrib>Matz, Timothy P.</creatorcontrib><creatorcontrib>Westby, Christian M.</creatorcontrib><creatorcontrib>Scott, Jessica M.</creatorcontrib><creatorcontrib>Stenger, Michael B.</creatorcontrib><creatorcontrib>Platts, Steven H.</creatorcontrib><title>Internal jugular pressure increases during parabolic flight</title><title>Physiological reports</title><addtitle>Physiol Rep</addtitle><description>One hypothesized contributor to vision changes experienced by >75% of International Space Station astronauts is elevated intracranial pressure (ICP). While no definitive data yet exist, elevated ICP might be secondary to the microgravity‐induced cephalad fluid shift, resulting in venous congestion (overfilling and distension) and inhibition of cerebrospinal and lymphatic fluid drainage from the skull. The objective of this study was to measure internal jugular venous pressure (IJVP) during normo‐ and hypo‐gravity as an index of venous congestion. IJVP was measured noninvasively using compression sonography at rest during end‐expiration in 11 normal, healthy subjects (3 M, 8 F) during normal gravity (1G; supine) and weightlessness (0G; seated) produced by parabolic flight. IJVP also was measured in two subjects during parabolas approximating Lunar (1/6G) and Martian gravity (1/3G). Finally, IJVP was measured during increased intrathoracic pressure produced using controlled Valsalva maneuvers. IJVP was higher in 0G than 1G (23.9 ± 5.6 vs. 9.9 ± 5.1 mmHg, mean ± SD P < 0.001) in all subjects, and IJVP increased as gravity levels decreased in two subjects. Finally, IJVP was greater in 0G than 1G at all expiration pressures (P < 0.01). Taken together, these data suggest that IJVP is elevated during acute exposure to reduced gravity and may be elevated further by conditions that increase intrathoracic pressure, a strong modulator of central venous pressure and IJVP. However, whether elevated IJVP, and perhaps consequent venous congestion, observed during acute microgravity exposure contribute to vision changes during long‐duration spaceflight is yet to be determined.
Internal jugular venous pressure (IJVP) was evaluated noninvasively before, and during reduced gravity in parabolic flight. While in microgravity, IJVP was higher in all 11 subjects (23.9 ± 5.6 vs. 9.9 ± 5.1 mmHg, P < 0.001).</description><subject>Adult</subject><subject>Astronauts</subject><subject>Blood Pressure</subject><subject>Catheters</subject><subject>Compression</subject><subject>Compression therapy</subject><subject>Distension</subject><subject>Female</subject><subject>Gravitation</subject><subject>Gravity</subject><subject>Humans</subject><subject>Hypogravity</subject><subject>Hypotheses</subject><subject>Jugular Veins - physiology</subject><subject>Laboratories</subject><subject>Male</subject><subject>Microgravity</subject><subject>Middle Aged</subject><subject>Neurological Conditions, Disorders and Treatments</subject><subject>Original Research</subject><subject>Participation</subject><subject>Physiology</subject><subject>Pressure</subject><subject>Respiration</subject><subject>Sensory Neuroscience</subject><subject>Space Flight</subject><subject>Spaceflight</subject><subject>Ultrasonic imaging</subject><subject>Veins & arteries</subject><subject>Venous Pressure</subject><subject>Visual impairment</subject><subject>visual impairment and intracranial pressure</subject><subject>Weightlessness</subject><subject>Weightlessness Simulation</subject><issn>2051-817X</issn><issn>2051-817X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc9LwzAUx4MoKtOTdyl4EaQzv9qmCIIMdYKgBwU9hTR52zKytiatsv_eblVRD-IlCbwPn7z3vggdEDwkXBB-Ws-WdEgYTsUG2qU4IbEg2dPmt_cO2g9hjjEmmLEc8220QwVmOcf5Ljq7KRvwpXLRvJ22Tvmo9hBC6yGypfagAoTItN6W06hWXhWVszqaODudNXtoa6JcgP2Pe4Aery4fRuP49u76ZnRxG-uEMBEbAMILpiYmNZxlNKXEqFRzIYygRigCzGieUA5KmQJUkWKWZUTzPIMECmADdN5767ZYgNFQNl45WXu7UH4pK2Xlz0ppZ3JavcqEdiNnpBMcfwh89dJCaOTCBg3OqRKqNkgikpzn3Tbz_6A8JTRNRIce_ULnVbtaZZCU5t3HeHUO0ElPaV-F4GHy1TfBch2hXEUo1xF29OH3Ub_Yz8A6gPbAm3Ww_Msl78fPtLe-A-lVpyk</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Martin, David S.</creator><creator>Lee, Stuart M. C.</creator><creator>Matz, Timothy P.</creator><creator>Westby, Christian M.</creator><creator>Scott, Jessica M.</creator><creator>Stenger, Michael B.</creator><creator>Platts, Steven H.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201612</creationdate><title>Internal jugular pressure increases during parabolic flight</title><author>Martin, David S. ; Lee, Stuart M. 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C.</creatorcontrib><creatorcontrib>Matz, Timothy P.</creatorcontrib><creatorcontrib>Westby, Christian M.</creatorcontrib><creatorcontrib>Scott, Jessica M.</creatorcontrib><creatorcontrib>Stenger, Michael B.</creatorcontrib><creatorcontrib>Platts, Steven H.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Physiological reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin, David S.</au><au>Lee, Stuart M. C.</au><au>Matz, Timothy P.</au><au>Westby, Christian M.</au><au>Scott, Jessica M.</au><au>Stenger, Michael B.</au><au>Platts, Steven H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Internal jugular pressure increases during parabolic flight</atitle><jtitle>Physiological reports</jtitle><addtitle>Physiol Rep</addtitle><date>2016-12</date><risdate>2016</risdate><volume>4</volume><issue>24</issue><spage>np</spage><epage>n/a</epage><pages>np-n/a</pages><issn>2051-817X</issn><eissn>2051-817X</eissn><abstract>One hypothesized contributor to vision changes experienced by >75% of International Space Station astronauts is elevated intracranial pressure (ICP). While no definitive data yet exist, elevated ICP might be secondary to the microgravity‐induced cephalad fluid shift, resulting in venous congestion (overfilling and distension) and inhibition of cerebrospinal and lymphatic fluid drainage from the skull. The objective of this study was to measure internal jugular venous pressure (IJVP) during normo‐ and hypo‐gravity as an index of venous congestion. IJVP was measured noninvasively using compression sonography at rest during end‐expiration in 11 normal, healthy subjects (3 M, 8 F) during normal gravity (1G; supine) and weightlessness (0G; seated) produced by parabolic flight. IJVP also was measured in two subjects during parabolas approximating Lunar (1/6G) and Martian gravity (1/3G). Finally, IJVP was measured during increased intrathoracic pressure produced using controlled Valsalva maneuvers. IJVP was higher in 0G than 1G (23.9 ± 5.6 vs. 9.9 ± 5.1 mmHg, mean ± SD P < 0.001) in all subjects, and IJVP increased as gravity levels decreased in two subjects. Finally, IJVP was greater in 0G than 1G at all expiration pressures (P < 0.01). Taken together, these data suggest that IJVP is elevated during acute exposure to reduced gravity and may be elevated further by conditions that increase intrathoracic pressure, a strong modulator of central venous pressure and IJVP. However, whether elevated IJVP, and perhaps consequent venous congestion, observed during acute microgravity exposure contribute to vision changes during long‐duration spaceflight is yet to be determined.
Internal jugular venous pressure (IJVP) was evaluated noninvasively before, and during reduced gravity in parabolic flight. While in microgravity, IJVP was higher in all 11 subjects (23.9 ± 5.6 vs. 9.9 ± 5.1 mmHg, P < 0.001).</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>28039409</pmid><doi>10.14814/phy2.13068</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Astronauts Blood Pressure Catheters Compression Compression therapy Distension Female Gravitation Gravity Humans Hypogravity Hypotheses Jugular Veins - physiology Laboratories Male Microgravity Middle Aged Neurological Conditions, Disorders and Treatments Original Research Participation Physiology Pressure Respiration Sensory Neuroscience Space Flight Spaceflight Ultrasonic imaging Veins & arteries Venous Pressure Visual impairment visual impairment and intracranial pressure Weightlessness Weightlessness Simulation |
| title | Internal jugular pressure increases during parabolic flight |
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