plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis
Transgenic Arabidopsis thaliana plants overproducing the E2Fa-DPa transcription factor have two distinct cell-specific phenotypes: some cells divide ectopically and others are stimulated to endocycle. The decision of cells to undergo extra mitotic divisions has been postulated to depend on the prese...
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| Veröffentlicht in: | The Plant cell 2004-10, Vol.16 (10), p.2683-2692 |
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| container_title | The Plant cell |
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| creator | Boudolf, V Vlieghe, K Beemster, G.T.S Magyar, Z Acosta, J.A.T Maes, S Schueren, E. van der Veylder, L. de |
| description | Transgenic Arabidopsis thaliana plants overproducing the E2Fa-DPa transcription factor have two distinct cell-specific phenotypes: some cells divide ectopically and others are stimulated to endocycle. The decision of cells to undergo extra mitotic divisions has been postulated to depend on the presence of a mitosis-inducing factor (MIF). Plants possess a unique class of cyclin-dependent kinases (CDKs; B-type) for which no ortholog is found in other kingdoms. The peak of CDKB1;1 activity around the G2-M boundary suggested that it might be part of the MIF. Plants that overexpressed a dominant negative allele of CDKB1;1 underwent enhanced endoreduplication, demonstrating that CDKB1;1 activity was required to inhibit the endocycle. Moreover, when the mutant CDKB1;1 allele was overexpressed in an E2Fa-DPa-overproducing background, it enhanced the endoreduplication phenotype, whereas the extra mitotic cell divisions normally induced by E2Fa-DPa were repressed. Surprisingly, CDKB1;1 transcription was controlled by the E2F pathway, as shown by its upregulation in E2Fa-DPa-overproducing plants and mutational analysis of the E2F binding site in the CDKB1;1 promoter. These findings illustrate a cross talking mechanism between the G1-S and G2-M transition points. |
| doi_str_mv | 10.1105/tpc.104.024398 |
| format | Article |
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The decision of cells to undergo extra mitotic divisions has been postulated to depend on the presence of a mitosis-inducing factor (MIF). Plants possess a unique class of cyclin-dependent kinases (CDKs; B-type) for which no ortholog is found in other kingdoms. The peak of CDKB1;1 activity around the G2-M boundary suggested that it might be part of the MIF. Plants that overexpressed a dominant negative allele of CDKB1;1 underwent enhanced endoreduplication, demonstrating that CDKB1;1 activity was required to inhibit the endocycle. Moreover, when the mutant CDKB1;1 allele was overexpressed in an E2Fa-DPa-overproducing background, it enhanced the endoreduplication phenotype, whereas the extra mitotic cell divisions normally induced by E2Fa-DPa were repressed. Surprisingly, CDKB1;1 transcription was controlled by the E2F pathway, as shown by its upregulation in E2Fa-DPa-overproducing plants and mutational analysis of the E2F binding site in the CDKB1;1 promoter. These findings illustrate a cross talking mechanism between the G1-S and G2-M transition points.</description><identifier>ISSN: 1040-4651</identifier><identifier>EISSN: 1532-298X</identifier><identifier>DOI: 10.1105/tpc.104.024398</identifier><identifier>PMID: 15377755</identifier><language>eng</language><publisher>United States: American Society of Plant Biologists</publisher><subject>Arabidopsis ; Arabidopsis - cytology ; Arabidopsis - enzymology ; Arabidopsis - metabolism ; Arabidopsis Proteins - metabolism ; Arabidopsis thaliana ; Base Sequence ; Cell cycle ; Cell Cycle Proteins - metabolism ; Cell division ; Cyclin-Dependent Kinases - metabolism ; DNA ; DNA ploidy ; DNA Primers ; DNA replication ; DNA-Binding Proteins - metabolism ; E2F Transcription Factors ; enzyme activity ; Epidermal cells ; gene expression ; gene overexpression ; leaf development ; Leaves ; messenger RNA ; Mitosis ; Plant cells ; Plant Leaves - cytology ; Plant Leaves - enzymology ; Plant Leaves - metabolism ; Plants ; Ploidies ; Reverse Transcriptase Polymerase Chain Reaction ; Sowing ; transcription (genetics) ; transcription factors ; Transcription Factors - metabolism ; Transgenic plants</subject><ispartof>The Plant cell, 2004-10, Vol.16 (10), p.2683-2692</ispartof><rights>Copyright 2004 American Society of Plant Biologists</rights><rights>Copyright American Society of Plant Physiologists Oct 2004</rights><rights>Copyright © 2004, American Society of Plant Biologists 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-ed07920bd7e3756cd4cbf333eb296fc08fc24d743f0fab5feeecd85f09239fb53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3872257$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3872257$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15377755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boudolf, V</creatorcontrib><creatorcontrib>Vlieghe, K</creatorcontrib><creatorcontrib>Beemster, G.T.S</creatorcontrib><creatorcontrib>Magyar, Z</creatorcontrib><creatorcontrib>Acosta, J.A.T</creatorcontrib><creatorcontrib>Maes, S</creatorcontrib><creatorcontrib>Schueren, E. van der</creatorcontrib><creatorcontrib>Veylder, L. de</creatorcontrib><title>plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis</title><title>The Plant cell</title><addtitle>Plant Cell</addtitle><description>Transgenic Arabidopsis thaliana plants overproducing the E2Fa-DPa transcription factor have two distinct cell-specific phenotypes: some cells divide ectopically and others are stimulated to endocycle. The decision of cells to undergo extra mitotic divisions has been postulated to depend on the presence of a mitosis-inducing factor (MIF). Plants possess a unique class of cyclin-dependent kinases (CDKs; B-type) for which no ortholog is found in other kingdoms. The peak of CDKB1;1 activity around the G2-M boundary suggested that it might be part of the MIF. Plants that overexpressed a dominant negative allele of CDKB1;1 underwent enhanced endoreduplication, demonstrating that CDKB1;1 activity was required to inhibit the endocycle. Moreover, when the mutant CDKB1;1 allele was overexpressed in an E2Fa-DPa-overproducing background, it enhanced the endoreduplication phenotype, whereas the extra mitotic cell divisions normally induced by E2Fa-DPa were repressed. Surprisingly, CDKB1;1 transcription was controlled by the E2F pathway, as shown by its upregulation in E2Fa-DPa-overproducing plants and mutational analysis of the E2F binding site in the CDKB1;1 promoter. These findings illustrate a cross talking mechanism between the G1-S and G2-M transition points.</description><subject>Arabidopsis</subject><subject>Arabidopsis - cytology</subject><subject>Arabidopsis - enzymology</subject><subject>Arabidopsis - metabolism</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Arabidopsis thaliana</subject><subject>Base Sequence</subject><subject>Cell cycle</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell division</subject><subject>Cyclin-Dependent Kinases - metabolism</subject><subject>DNA</subject><subject>DNA ploidy</subject><subject>DNA Primers</subject><subject>DNA replication</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>E2F Transcription Factors</subject><subject>enzyme activity</subject><subject>Epidermal cells</subject><subject>gene expression</subject><subject>gene overexpression</subject><subject>leaf development</subject><subject>Leaves</subject><subject>messenger RNA</subject><subject>Mitosis</subject><subject>Plant cells</subject><subject>Plant Leaves - cytology</subject><subject>Plant Leaves - enzymology</subject><subject>Plant Leaves - metabolism</subject><subject>Plants</subject><subject>Ploidies</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Sowing</subject><subject>transcription (genetics)</subject><subject>transcription factors</subject><subject>Transcription Factors - metabolism</subject><subject>Transgenic plants</subject><issn>1040-4651</issn><issn>1532-298X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkj1vFDEQhlcIREKgpUJgUdDtMbbX67UQRbgkgIgEEkSis7z-uPjYsxfbFym_iL-Jw53CR0Plkd9nZjzjt2keY1hgDOxlmfUCQ7cA0lEx3GkOMaOkJWL4erfG0EHb9QwfNA9yXgMA5ljcbw4qxDln7LD5MU8qlDbPVnvnNdLXevKhNXa2wdhQ0DcfVLZoefLhDX6FkQoGlaRC1snPxceAnNIlJnRKzlR78kkhHUNJcULl0qJR1eraoujQxpdYvFbTdI2Mv_LGh9WvarVPTNZs56mq5eZW22nKyAd0nNToTZyzzw-be05N2T7an0fNxdnpl-W79vzj2_fL4_NWMwGltQa4IDAabilnvTadHh2l1I5E9E7D4DTpDO-oA6dG5qy12gzMgSBUuJHRo-b1ru68HTfW6LqCpCY5J79R6VpG5eXfSvCXchWvJCMg-q7mv9jnp_h9a3ORG59vBlLBxm2WfS86zOD_IOaEM-ihgs__Addxm0JdgiR44HRgQlRosYN0ijkn625fjEHeGEVWo9S4kzuj1ISnf875G987owJPdsA61--91enACWG8ys92slNRqlXyWV58JoApgGCck57-BIvm0Ko</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Boudolf, V</creator><creator>Vlieghe, K</creator><creator>Beemster, G.T.S</creator><creator>Magyar, Z</creator><creator>Acosta, J.A.T</creator><creator>Maes, S</creator><creator>Schueren, E. van der</creator><creator>Veylder, L. de</creator><general>American Society of Plant Biologists</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7QO</scope><scope>7TM</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20041001</creationdate><title>plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis</title><author>Boudolf, V ; Vlieghe, K ; Beemster, G.T.S ; Magyar, Z ; Acosta, J.A.T ; Maes, S ; Schueren, E. van der ; Veylder, L. de</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c590t-ed07920bd7e3756cd4cbf333eb296fc08fc24d743f0fab5feeecd85f09239fb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Arabidopsis</topic><topic>Arabidopsis - cytology</topic><topic>Arabidopsis - enzymology</topic><topic>Arabidopsis - metabolism</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>Arabidopsis thaliana</topic><topic>Base Sequence</topic><topic>Cell cycle</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cell division</topic><topic>Cyclin-Dependent Kinases - metabolism</topic><topic>DNA</topic><topic>DNA ploidy</topic><topic>DNA Primers</topic><topic>DNA replication</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>E2F Transcription Factors</topic><topic>enzyme activity</topic><topic>Epidermal cells</topic><topic>gene expression</topic><topic>gene overexpression</topic><topic>leaf development</topic><topic>Leaves</topic><topic>messenger RNA</topic><topic>Mitosis</topic><topic>Plant cells</topic><topic>Plant Leaves - cytology</topic><topic>Plant Leaves - enzymology</topic><topic>Plant Leaves - metabolism</topic><topic>Plants</topic><topic>Ploidies</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Sowing</topic><topic>transcription (genetics)</topic><topic>transcription factors</topic><topic>Transcription Factors - metabolism</topic><topic>Transgenic plants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boudolf, V</creatorcontrib><creatorcontrib>Vlieghe, K</creatorcontrib><creatorcontrib>Beemster, G.T.S</creatorcontrib><creatorcontrib>Magyar, Z</creatorcontrib><creatorcontrib>Acosta, J.A.T</creatorcontrib><creatorcontrib>Maes, S</creatorcontrib><creatorcontrib>Schueren, E. van der</creatorcontrib><creatorcontrib>Veylder, L. de</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Plant cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boudolf, V</au><au>Vlieghe, K</au><au>Beemster, G.T.S</au><au>Magyar, Z</au><au>Acosta, J.A.T</au><au>Maes, S</au><au>Schueren, E. van der</au><au>Veylder, L. de</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis</atitle><jtitle>The Plant cell</jtitle><addtitle>Plant Cell</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>16</volume><issue>10</issue><spage>2683</spage><epage>2692</epage><pages>2683-2692</pages><issn>1040-4651</issn><eissn>1532-298X</eissn><abstract>Transgenic Arabidopsis thaliana plants overproducing the E2Fa-DPa transcription factor have two distinct cell-specific phenotypes: some cells divide ectopically and others are stimulated to endocycle. The decision of cells to undergo extra mitotic divisions has been postulated to depend on the presence of a mitosis-inducing factor (MIF). Plants possess a unique class of cyclin-dependent kinases (CDKs; B-type) for which no ortholog is found in other kingdoms. The peak of CDKB1;1 activity around the G2-M boundary suggested that it might be part of the MIF. Plants that overexpressed a dominant negative allele of CDKB1;1 underwent enhanced endoreduplication, demonstrating that CDKB1;1 activity was required to inhibit the endocycle. Moreover, when the mutant CDKB1;1 allele was overexpressed in an E2Fa-DPa-overproducing background, it enhanced the endoreduplication phenotype, whereas the extra mitotic cell divisions normally induced by E2Fa-DPa were repressed. Surprisingly, CDKB1;1 transcription was controlled by the E2F pathway, as shown by its upregulation in E2Fa-DPa-overproducing plants and mutational analysis of the E2F binding site in the CDKB1;1 promoter. These findings illustrate a cross talking mechanism between the G1-S and G2-M transition points.</abstract><cop>United States</cop><pub>American Society of Plant Biologists</pub><pmid>15377755</pmid><doi>10.1105/tpc.104.024398</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Arabidopsis Arabidopsis - cytology Arabidopsis - enzymology Arabidopsis - metabolism Arabidopsis Proteins - metabolism Arabidopsis thaliana Base Sequence Cell cycle Cell Cycle Proteins - metabolism Cell division Cyclin-Dependent Kinases - metabolism DNA DNA ploidy DNA Primers DNA replication DNA-Binding Proteins - metabolism E2F Transcription Factors enzyme activity Epidermal cells gene expression gene overexpression leaf development Leaves messenger RNA Mitosis Plant cells Plant Leaves - cytology Plant Leaves - enzymology Plant Leaves - metabolism Plants Ploidies Reverse Transcriptase Polymerase Chain Reaction Sowing transcription (genetics) transcription factors Transcription Factors - metabolism Transgenic plants |
| title | plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis |
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