Transcriptional dysregulation causes altered modulation of inhibition by haloperidol

Many neuropsychiatric and neurodevelopmental disorders such as schizophrenia and autism involve interneuron transcriptional dysregulation. The transcriptional coactivator PGC-1α regulates gene expression in GABAergic interneurons, which are important for regulating hippocampal network activity. Gene...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuropharmacology 2016-12, Vol.111, p.304-313
Hauptverfasser:	Brady, Lillian J., Bartley, Aundrea F., Li, Qin, McMeekin, Laura J., Hablitz, John J., Cowell, Rita M., Dobrunz, Lynn E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotic Agents - administration & dosage CA1 CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - physiology Cells, Cultured Dopamine Dopamine D2 Receptor Antagonists Excitatory Postsynaptic Potentials - drug effects Female Gamma Rhythm - drug effects Gene Expression Regulation Haloperidol - administration & dosage Hippocampus Indoles - administration & dosage Indoles - pharmacology Inhibitory Postsynaptic Potentials - drug effects Interneurons - drug effects Interneurons - metabolism Male Mice Mice, Knockout Nesting Behavior - drug effects Neural Inhibition - drug effects Parvalbumin Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism PGC-1α Piperidines - administration & dosage Piperidines - pharmacology Receptors, Dopamine D2 - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!