Benzyl Isothiocyanate (BITC) Induces Reactive Oxygen Species-dependent Repression of STAT3 Protein by Down-regulation of Specificity Proteins in Pancreatic Cancer

The antineoplastic agent benzyl isothiocyanate (BITC) acts by targeting multiple pro-oncogenic pathways/genes, including signal transducer and activator of transcription 3 (STAT3); however, the mechanism of action is not well known. As reported previously, BITC induced reactive oxygen species (ROS)...

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Veröffentlicht in:	The Journal of biological chemistry 2016-12, Vol.291 (53), p.27122-27133
Hauptverfasser:	Kasiappan, Ravi, Jutooru, Indira, Karki, Keshav, Hedrick, Erik, Safe, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Blotting, Western Cell Movement - drug effects Cell Proliferation - drug effects Gene Expression Regulation, Neoplastic - drug effects Gene Regulation Humans Isothiocyanates - pharmacology Mice Mice, Nude Myc (c-Myc) pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology reactive oxygen species (ROS) Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Sp Transcription Factors - antagonists & inhibitors Sp Transcription Factors - genetics Sp Transcription Factors - metabolism specificity protein 1 (Sp1) STAT3 STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism STAT3 Transcription Factor - therapeutic use Tumor Cells, Cultured Xenograft Model Antitumor Assays
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