Natural and Induced Mitochondrial Phosphate Carrier Loss: DIFFERENTIAL DEPENDENCE OF MITOCHONDRIAL METABOLISM AND DYNAMICS AND CELL SURVIVAL ON THE EXTENT OF DEPLETION

The relevance of mitochondrial phosphate carrier (PiC), encoded by SLC25A3, in bioenergetics is well accepted. However, little is known about the mechanisms mediating the cellular impairments induced by pathological SLC25A3 variants. To this end, we investigated the pathogenicity of a novel compound...

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Veröffentlicht in:	The Journal of biological chemistry 2016-12, Vol.291 (50), p.26126-26137
Hauptverfasser:	Seifert, Erin L, Gál, Aniko, Acoba, Michelle G, Li, Qipei, Anderson-Pullinger, Lauren, Golenár, Tunde, Moffat, Cynthia, Sondheimer, Neal, Claypool, Steven M, Hajnóczky, György
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Bioenergetics Cell Survival GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism HeLa Cells Humans Mitochondria - genetics Mitochondria - metabolism Mitochondrial Membrane Transport Proteins - genetics Mitochondrial Membrane Transport Proteins - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Mutation, Missense Oxidative Phosphorylation Phosphate Transport Proteins - genetics Phosphate Transport Proteins - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism
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