Original Research: Potential ocular protection and dynamic observation of Polygonatum sibiricum polysaccharide against streptozocin-induced diabetic rats’ model
Ocular complications associated with diabetes mellitus are progressive and becoming one of the most important causes of morbidity worldwide. The purpose of the study is to evaluate the protective effect of Polygonatum sibiricum polysaccharide, an important component of Polygonatum sibiricum, on ocul...
Gespeichert in:
| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 2017-01, Vol.242 (1), p.92-101 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 101 |
|---|---|
| container_issue | 1 |
| container_start_page | 92 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 242 |
| creator | Wang, Yi Qin, Shucun Pen, Guoqing Chen, Di Han, Chao Miao, Chunrun Lu, Baojin Su, Chao Feng, Shanlong Li, Wen Han, Jingjing Cho, Nam C Si, Yanhong |
| description | Ocular complications associated with diabetes mellitus are progressive and becoming one of the most important causes of morbidity worldwide. The purpose of the study is to evaluate the protective effect of Polygonatum sibiricum polysaccharide, an important component of Polygonatum sibiricum, on ocular complications in streptozotocin-induced diabetes mellitus rats. Sprague Dawley rats were made diabetic with streptozotocin(60 mg/kg, i.v.) and then the rats were treated with Polygonatum sibiricum polysaccharide 200, 400 and 800 mg/kg.d by gavage for 12 weeks. Biochemical analysis indicated that Polygonatum sibiricum polysaccharide lowered the levels of fasting blood glucose and glycated hemoglobin in blood and elevated the levels of insulin and C-peptide in plasma of diabetes mellitus rats in a dose-dependent manner. Physical measurements revealed that Polygonatum sibiricum polysaccharide improved clinical symptoms of polydipsia, polyphagia, polyuria and weight loss in diabetes mellitus rats. The content of malondialdehyde and activity of superoxide dismutase in plasma were determined, and the data showed Polygonatum sibiricum polysaccharide suppressed oxidative stress reaction. Lens opacification was observed using slit lamp illumination, and the data showed Polygonatum sibiricum polysaccharide delayed cataract progression in a dose-dependent manner. Electroretinogram showed Polygonatum sibiricum polysaccharide treatment reversed the decrease of electroretinogram b and OPs2 waves’ amplitudes. Flash-visual evoked potential test indicated that the peak time of P2 wave was prolonged, and the amplitude of N2-P2 was lowered in diabetes mellitus group, and Polygonatum sibiricum polysaccharide suppressed these changes. Fundus fluorescein angiography showed Polygonatum sibiricum polysaccharide alleviated the retinal vasculopathy in a dose-dependent manner. In conclusion, these results suggest that the administration of Polygonatum sibiricum polysaccharide slows the progression of diabetic retinopathy and cataract through alleviating hyperglycemia and reducing oxidative stress in streptozotocin-induced diabetes mellitus rats. |
| doi_str_mv | 10.1177/1535370216663866 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5206980</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1535370216663866</sage_id><sourcerecordid>1846365348</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3496-9d25003ad42b56195f8201688863e5bd49c4e5b5281021c6f87b146a7e43a5753</originalsourceid><addsrcrecordid>eNp1kc1u1TAQhS0EoqWwZ4W8ZBPwT-w4LJBQxZ9UqQjB2prYTq6rxA62U-my4jXY8mg8CS63rQCJ1YzOnPlszUHoMSXPKO2651RwwTvCqJSSKynvoOMrqeGy7-_e9HV-hB7kfEEIFR2T99ER6wQlQrFj9OM8-ckHmPFHlx0ks3uBP8TiQvFVi2abIeE1VcUUHwOGYLHdB1i8wXHILl3Cbz2OdW3eTzFA2Rac_eCTN7Vbq5rBmB0kbx2GCXzIBeeS3Fri12h8aHywm3EV7GFwpZITlPzz23e8ROvmh-jeCHN2j67rCfr85vWn03fN2fnb96evzhrD2142vWWCEA62ZYOQtBejYoRKpZTkTgy27U1bq2CK1oMZOapuoK2EzrUcRCf4CXp54K7bsDhr6g0SzHpNfoG01xG8_nsS_E5P8VILRmSvSAU8vQak-GVzuejFZ-PmGYKLW9ZUtZJLwVtVreRgNSnmnNx4-wwl-ipa_W-0deXJn9-7XbjJshqagyHD5PRF3FKNNf8f-AujZbEv</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1846365348</pqid></control><display><type>article</type><title>Original Research: Potential ocular protection and dynamic observation of Polygonatum sibiricum polysaccharide against streptozocin-induced diabetic rats’ model</title><source>MEDLINE</source><source>PubMed Central</source><source>SAGE Journals</source><source>EZB Electronic Journals Library</source><creator>Wang, Yi ; Qin, Shucun ; Pen, Guoqing ; Chen, Di ; Han, Chao ; Miao, Chunrun ; Lu, Baojin ; Su, Chao ; Feng, Shanlong ; Li, Wen ; Han, Jingjing ; Cho, Nam C ; Si, Yanhong</creator><creatorcontrib>Wang, Yi ; Qin, Shucun ; Pen, Guoqing ; Chen, Di ; Han, Chao ; Miao, Chunrun ; Lu, Baojin ; Su, Chao ; Feng, Shanlong ; Li, Wen ; Han, Jingjing ; Cho, Nam C ; Si, Yanhong</creatorcontrib><description>Ocular complications associated with diabetes mellitus are progressive and becoming one of the most important causes of morbidity worldwide. The purpose of the study is to evaluate the protective effect of Polygonatum sibiricum polysaccharide, an important component of Polygonatum sibiricum, on ocular complications in streptozotocin-induced diabetes mellitus rats. Sprague Dawley rats were made diabetic with streptozotocin(60 mg/kg, i.v.) and then the rats were treated with Polygonatum sibiricum polysaccharide 200, 400 and 800 mg/kg.d by gavage for 12 weeks. Biochemical analysis indicated that Polygonatum sibiricum polysaccharide lowered the levels of fasting blood glucose and glycated hemoglobin in blood and elevated the levels of insulin and C-peptide in plasma of diabetes mellitus rats in a dose-dependent manner. Physical measurements revealed that Polygonatum sibiricum polysaccharide improved clinical symptoms of polydipsia, polyphagia, polyuria and weight loss in diabetes mellitus rats. The content of malondialdehyde and activity of superoxide dismutase in plasma were determined, and the data showed Polygonatum sibiricum polysaccharide suppressed oxidative stress reaction. Lens opacification was observed using slit lamp illumination, and the data showed Polygonatum sibiricum polysaccharide delayed cataract progression in a dose-dependent manner. Electroretinogram showed Polygonatum sibiricum polysaccharide treatment reversed the decrease of electroretinogram b and OPs2 waves’ amplitudes. Flash-visual evoked potential test indicated that the peak time of P2 wave was prolonged, and the amplitude of N2-P2 was lowered in diabetes mellitus group, and Polygonatum sibiricum polysaccharide suppressed these changes. Fundus fluorescein angiography showed Polygonatum sibiricum polysaccharide alleviated the retinal vasculopathy in a dose-dependent manner. In conclusion, these results suggest that the administration of Polygonatum sibiricum polysaccharide slows the progression of diabetic retinopathy and cataract through alleviating hyperglycemia and reducing oxidative stress in streptozotocin-induced diabetes mellitus rats.</description><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.1177/1535370216663866</identifier><identifier>PMID: 27510582</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Cataract - drug therapy ; Cataract - etiology ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - metabolism ; Diabetic Retinopathy - drug therapy ; Electroretinography ; Evoked Potentials, Visual - drug effects ; Glucose - metabolism ; Glycated Hemoglobin A - metabolism ; Hypoglycemic Agents - pharmacology ; Male ; Pharmacology & Toxicology ; Plants, Medicinal - chemistry ; Polydipsia - drug therapy ; Polydipsia - etiology ; Polygonatum - chemistry ; Polysaccharides - pharmacology ; Polyuria - drug therapy ; Rats, Sprague-Dawley ; Streptozocin</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 2017-01, Vol.242 (1), p.92-101</ispartof><rights>2016 by the Society for Experimental Biology and Medicine</rights><rights>2016 by the Society for Experimental Biology and Medicine.</rights><rights>2016 by the Society for Experimental Biology and Medicine 2016 The Society for Experimental Biology and Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3496-9d25003ad42b56195f8201688863e5bd49c4e5b5281021c6f87b146a7e43a5753</citedby><cites>FETCH-LOGICAL-c3496-9d25003ad42b56195f8201688863e5bd49c4e5b5281021c6f87b146a7e43a5753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206980/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206980/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,21798,27901,27902,43597,43598,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27510582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Qin, Shucun</creatorcontrib><creatorcontrib>Pen, Guoqing</creatorcontrib><creatorcontrib>Chen, Di</creatorcontrib><creatorcontrib>Han, Chao</creatorcontrib><creatorcontrib>Miao, Chunrun</creatorcontrib><creatorcontrib>Lu, Baojin</creatorcontrib><creatorcontrib>Su, Chao</creatorcontrib><creatorcontrib>Feng, Shanlong</creatorcontrib><creatorcontrib>Li, Wen</creatorcontrib><creatorcontrib>Han, Jingjing</creatorcontrib><creatorcontrib>Cho, Nam C</creatorcontrib><creatorcontrib>Si, Yanhong</creatorcontrib><title>Original Research: Potential ocular protection and dynamic observation of Polygonatum sibiricum polysaccharide against streptozocin-induced diabetic rats’ model</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Exp Biol Med (Maywood)</addtitle><description>Ocular complications associated with diabetes mellitus are progressive and becoming one of the most important causes of morbidity worldwide. The purpose of the study is to evaluate the protective effect of Polygonatum sibiricum polysaccharide, an important component of Polygonatum sibiricum, on ocular complications in streptozotocin-induced diabetes mellitus rats. Sprague Dawley rats were made diabetic with streptozotocin(60 mg/kg, i.v.) and then the rats were treated with Polygonatum sibiricum polysaccharide 200, 400 and 800 mg/kg.d by gavage for 12 weeks. Biochemical analysis indicated that Polygonatum sibiricum polysaccharide lowered the levels of fasting blood glucose and glycated hemoglobin in blood and elevated the levels of insulin and C-peptide in plasma of diabetes mellitus rats in a dose-dependent manner. Physical measurements revealed that Polygonatum sibiricum polysaccharide improved clinical symptoms of polydipsia, polyphagia, polyuria and weight loss in diabetes mellitus rats. The content of malondialdehyde and activity of superoxide dismutase in plasma were determined, and the data showed Polygonatum sibiricum polysaccharide suppressed oxidative stress reaction. Lens opacification was observed using slit lamp illumination, and the data showed Polygonatum sibiricum polysaccharide delayed cataract progression in a dose-dependent manner. Electroretinogram showed Polygonatum sibiricum polysaccharide treatment reversed the decrease of electroretinogram b and OPs2 waves’ amplitudes. Flash-visual evoked potential test indicated that the peak time of P2 wave was prolonged, and the amplitude of N2-P2 was lowered in diabetes mellitus group, and Polygonatum sibiricum polysaccharide suppressed these changes. Fundus fluorescein angiography showed Polygonatum sibiricum polysaccharide alleviated the retinal vasculopathy in a dose-dependent manner. In conclusion, these results suggest that the administration of Polygonatum sibiricum polysaccharide slows the progression of diabetic retinopathy and cataract through alleviating hyperglycemia and reducing oxidative stress in streptozotocin-induced diabetes mellitus rats.</description><subject>Animals</subject><subject>Cataract - drug therapy</subject><subject>Cataract - etiology</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetic Retinopathy - drug therapy</subject><subject>Electroretinography</subject><subject>Evoked Potentials, Visual - drug effects</subject><subject>Glucose - metabolism</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Male</subject><subject>Pharmacology & Toxicology</subject><subject>Plants, Medicinal - chemistry</subject><subject>Polydipsia - drug therapy</subject><subject>Polydipsia - etiology</subject><subject>Polygonatum - chemistry</subject><subject>Polysaccharides - pharmacology</subject><subject>Polyuria - drug therapy</subject><subject>Rats, Sprague-Dawley</subject><subject>Streptozocin</subject><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1TAQhS0EoqWwZ4W8ZBPwT-w4LJBQxZ9UqQjB2prYTq6rxA62U-my4jXY8mg8CS63rQCJ1YzOnPlszUHoMSXPKO2651RwwTvCqJSSKynvoOMrqeGy7-_e9HV-hB7kfEEIFR2T99ER6wQlQrFj9OM8-ckHmPFHlx0ks3uBP8TiQvFVi2abIeE1VcUUHwOGYLHdB1i8wXHILl3Cbz2OdW3eTzFA2Rac_eCTN7Vbq5rBmB0kbx2GCXzIBeeS3Fri12h8aHywm3EV7GFwpZITlPzz23e8ROvmh-jeCHN2j67rCfr85vWn03fN2fnb96evzhrD2142vWWCEA62ZYOQtBejYoRKpZTkTgy27U1bq2CK1oMZOapuoK2EzrUcRCf4CXp54K7bsDhr6g0SzHpNfoG01xG8_nsS_E5P8VILRmSvSAU8vQak-GVzuejFZ-PmGYKLW9ZUtZJLwVtVreRgNSnmnNx4-wwl-ipa_W-0deXJn9-7XbjJshqagyHD5PRF3FKNNf8f-AujZbEv</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Wang, Yi</creator><creator>Qin, Shucun</creator><creator>Pen, Guoqing</creator><creator>Chen, Di</creator><creator>Han, Chao</creator><creator>Miao, Chunrun</creator><creator>Lu, Baojin</creator><creator>Su, Chao</creator><creator>Feng, Shanlong</creator><creator>Li, Wen</creator><creator>Han, Jingjing</creator><creator>Cho, Nam C</creator><creator>Si, Yanhong</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>Original Research: Potential ocular protection and dynamic observation of Polygonatum sibiricum polysaccharide against streptozocin-induced diabetic rats’ model</title><author>Wang, Yi ; Qin, Shucun ; Pen, Guoqing ; Chen, Di ; Han, Chao ; Miao, Chunrun ; Lu, Baojin ; Su, Chao ; Feng, Shanlong ; Li, Wen ; Han, Jingjing ; Cho, Nam C ; Si, Yanhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3496-9d25003ad42b56195f8201688863e5bd49c4e5b5281021c6f87b146a7e43a5753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Cataract - drug therapy</topic><topic>Cataract - etiology</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetic Retinopathy - drug therapy</topic><topic>Electroretinography</topic><topic>Evoked Potentials, Visual - drug effects</topic><topic>Glucose - metabolism</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Male</topic><topic>Pharmacology & Toxicology</topic><topic>Plants, Medicinal - chemistry</topic><topic>Polydipsia - drug therapy</topic><topic>Polydipsia - etiology</topic><topic>Polygonatum - chemistry</topic><topic>Polysaccharides - pharmacology</topic><topic>Polyuria - drug therapy</topic><topic>Rats, Sprague-Dawley</topic><topic>Streptozocin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Qin, Shucun</creatorcontrib><creatorcontrib>Pen, Guoqing</creatorcontrib><creatorcontrib>Chen, Di</creatorcontrib><creatorcontrib>Han, Chao</creatorcontrib><creatorcontrib>Miao, Chunrun</creatorcontrib><creatorcontrib>Lu, Baojin</creatorcontrib><creatorcontrib>Su, Chao</creatorcontrib><creatorcontrib>Feng, Shanlong</creatorcontrib><creatorcontrib>Li, Wen</creatorcontrib><creatorcontrib>Han, Jingjing</creatorcontrib><creatorcontrib>Cho, Nam C</creatorcontrib><creatorcontrib>Si, Yanhong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yi</au><au>Qin, Shucun</au><au>Pen, Guoqing</au><au>Chen, Di</au><au>Han, Chao</au><au>Miao, Chunrun</au><au>Lu, Baojin</au><au>Su, Chao</au><au>Feng, Shanlong</au><au>Li, Wen</au><au>Han, Jingjing</au><au>Cho, Nam C</au><au>Si, Yanhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Original Research: Potential ocular protection and dynamic observation of Polygonatum sibiricum polysaccharide against streptozocin-induced diabetic rats’ model</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Exp Biol Med (Maywood)</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>242</volume><issue>1</issue><spage>92</spage><epage>101</epage><pages>92-101</pages><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Ocular complications associated with diabetes mellitus are progressive and becoming one of the most important causes of morbidity worldwide. The purpose of the study is to evaluate the protective effect of Polygonatum sibiricum polysaccharide, an important component of Polygonatum sibiricum, on ocular complications in streptozotocin-induced diabetes mellitus rats. Sprague Dawley rats were made diabetic with streptozotocin(60 mg/kg, i.v.) and then the rats were treated with Polygonatum sibiricum polysaccharide 200, 400 and 800 mg/kg.d by gavage for 12 weeks. Biochemical analysis indicated that Polygonatum sibiricum polysaccharide lowered the levels of fasting blood glucose and glycated hemoglobin in blood and elevated the levels of insulin and C-peptide in plasma of diabetes mellitus rats in a dose-dependent manner. Physical measurements revealed that Polygonatum sibiricum polysaccharide improved clinical symptoms of polydipsia, polyphagia, polyuria and weight loss in diabetes mellitus rats. The content of malondialdehyde and activity of superoxide dismutase in plasma were determined, and the data showed Polygonatum sibiricum polysaccharide suppressed oxidative stress reaction. Lens opacification was observed using slit lamp illumination, and the data showed Polygonatum sibiricum polysaccharide delayed cataract progression in a dose-dependent manner. Electroretinogram showed Polygonatum sibiricum polysaccharide treatment reversed the decrease of electroretinogram b and OPs2 waves’ amplitudes. Flash-visual evoked potential test indicated that the peak time of P2 wave was prolonged, and the amplitude of N2-P2 was lowered in diabetes mellitus group, and Polygonatum sibiricum polysaccharide suppressed these changes. Fundus fluorescein angiography showed Polygonatum sibiricum polysaccharide alleviated the retinal vasculopathy in a dose-dependent manner. In conclusion, these results suggest that the administration of Polygonatum sibiricum polysaccharide slows the progression of diabetic retinopathy and cataract through alleviating hyperglycemia and reducing oxidative stress in streptozotocin-induced diabetes mellitus rats.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>27510582</pmid><doi>10.1177/1535370216663866</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1535-3702 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 2017-01, Vol.242 (1), p.92-101 |
| issn | 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5206980 |
| source | MEDLINE; PubMed Central; SAGE Journals; EZB Electronic Journals Library |
| subjects | Animals Cataract - drug therapy Cataract - etiology Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetic Retinopathy - drug therapy Electroretinography Evoked Potentials, Visual - drug effects Glucose - metabolism Glycated Hemoglobin A - metabolism Hypoglycemic Agents - pharmacology Male Pharmacology & Toxicology Plants, Medicinal - chemistry Polydipsia - drug therapy Polydipsia - etiology Polygonatum - chemistry Polysaccharides - pharmacology Polyuria - drug therapy Rats, Sprague-Dawley Streptozocin |
| title | Original Research: Potential ocular protection and dynamic observation of Polygonatum sibiricum polysaccharide against streptozocin-induced diabetic rats’ model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T14%3A08%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Original%20Research:%20Potential%20ocular%20protection%20and%20dynamic%20observation%20of%20Polygonatum%20sibiricum%20polysaccharide%20against%20streptozocin-induced%20diabetic%20rats%E2%80%99%20model&rft.jtitle=Experimental%20biology%20and%20medicine%20(Maywood,%20N.J.)&rft.au=Wang,%20Yi&rft.date=2017-01-01&rft.volume=242&rft.issue=1&rft.spage=92&rft.epage=101&rft.pages=92-101&rft.issn=1535-3702&rft.eissn=1535-3699&rft_id=info:doi/10.1177/1535370216663866&rft_dat=%3Cproquest_pubme%3E1846365348%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1846365348&rft_id=info:pmid/27510582&rft_sage_id=10.1177_1535370216663866&rfr_iscdi=true |