Inflammation, oxidative stress and apoptosis cascade implications in bisphenol A‐induced liver fibrosis in male rats

Summary Bisphenol A (BPA) is a key monomer in the production of plastics. It has been shown to be hepatotoxic. Inflammation and oxidative stress are closely linked with liver fibrosis, the major contributing factor to hepatic failure. Therefore, the aim of this study was to evaluate the impact of ch...

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Veröffentlicht in:	International journal of experimental pathology 2016-10, Vol.97 (5), p.369-379
Hauptverfasser:	Elswefy, Sahar El‐Sayed, Abdallah, Fatma Rizk, Atteia, Hebatallah Husseini, Wahba, Alaa Samir, Hasan, Rehab Abdallah
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Apoptosis - drug effects Apoptosis - physiology Benzhydryl Compounds - administration & dosage Benzhydryl Compounds - pharmacology Benzhydryl Compounds - toxicity Biomarkers - metabolism Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Cytokines - blood Drug Administration Schedule Environmental Pollutants - administration & dosage Environmental Pollutants - pharmacology Environmental Pollutants - toxicity Extracellular Matrix - metabolism IL‐1β/IL‐10 Inflammation Mediators - metabolism Liver - metabolism Liver Cirrhosis - chemically induced Liver Cirrhosis - metabolism Liver Cirrhosis - pathology liver fibrosis Liver Function Tests - methods Male Malondialdehyde - metabolism Matrix Metalloproteinase 9 - metabolism matrix metalloproteinase‐9 Original oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Phenols - administration & dosage Phenols - pharmacology Phenols - toxicity Rats, Wistar tissue inhibitor of matrix metalloproteinase‐2 Tissue Inhibitor of Metalloproteinase-2 - metabolism
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