Facile Fabrication of Tumor Redox-Sensitive Nanoassemblies of Small-Molecule Oleate Prodrug as Potent Chemotherapeutic Nanomedicine

The conjugate of paclitaxel (PTX) and docosahexaenoic acid has entered into clinical trials. However, the most recent clinical outcomes fell short of expectations, due to the extremely slow drug release from the hydrophobic conjugates. Herein, a novel prodrug‐based nanoplatform self‐assembled by the...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2016-12, Vol.12 (46), p.6353-6362
Hauptverfasser:	Luo, Cong, Sun, Jin, Sun, Bingjun, Liu, Dan, Miao, Lei, Goodwin, Tyler Jay, Huang, Leaf, He, Zhonggui
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties cancer therapy Chemical compounds Conjugates disulfide bonds Drug delivery systems Drugs Effectiveness Fatty acids Nanostructure Nanotechnology oleate prodrugs paclitaxel prodrug-nanosystems Tumors
Online-Zugang:	Volltext
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