Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury

Alveolar epithelial regeneration is essential for resolution of the acute respiratory distress syndrome (ARDS). Although neutrophils have traditionally been considered mediators of epithelial damage, recent studies suggest they promote type II pneumocyte (AT2) proliferation, which is essential for r...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2016-12, Vol.311 (6), p.L1062-L1075
Hauptverfasser:	Paris, Andrew J, Liu, Yuhong, Mei, Junjie, Dai, Ning, Guo, Lei, Spruce, Lynn A, Hudock, Kristin M, Brenner, Jacob S, Zacharias, William J, Mei, Hankun D, Slamowitz, April R, Bhamidipati, Kartik, Beers, Michael F, Seeholzer, Steven H, Morrisey, Edward E, Worthen, G Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Acute Lung Injury - chemically induced Acute Lung Injury - pathology Alveolar Epithelial Cells - drug effects Alveolar Epithelial Cells - metabolism Alveolar Epithelial Cells - pathology Animals Antibodies - pharmacology Bronchoalveolar Lavage Fluid Cell Proliferation - drug effects Cytokines Disease Models, Animal Epithelium - drug effects Epithelium - pathology Granulocyte Colony-Stimulating Factor - deficiency Granulocyte Colony-Stimulating Factor - metabolism Immune response Mice, Inbred C57BL Neutrophils - drug effects Neutrophils - metabolism Neutrophils - pathology Proteins Proteomics Regeneration - drug effects Respiratory distress syndrome Respiratory Distress Syndrome - pathology Rodents Signal Transduction - drug effects Up-Regulation - drug effects Wound Healing - drug effects
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