Evolutionary patterns of metazoan microRNAs reveal targeting principles in the let-7 and miR-10 families

MicroRNAs (miRNAs) regulate gene output by targeting degenerate elements in mRNAs and have undergone drastic expansions in higher metazoan genomes. The evolutionary advantage of maintaining copies of highly similar miRNAs is not well understood, nor is it clear what unique functions, if any, miRNA f...

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Veröffentlicht in:	Genome research 2017-01, Vol.27 (1), p.53-63
Hauptverfasser:	Wolter, Justin M, Le, Hoai Huang Thi, Linse, Alexander, Godlove, Victoria A, Nguyen, Thuy-Duyen, Kotagama, Kasuen, Lynch, Alissa, Rawls, Alan, Mangone, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Conserved Sequence - genetics Drosophila - genetics Evolution, Molecular Gene Expression Regulation Humans Metazoa Mice MicroRNAs - genetics Multigene Family - genetics Nematoda - genetics Nucleic Acid Conformation Phylogeny RNA, Messenger - genetics
Online-Zugang:	Volltext
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