Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein Armus

The class III phosphoinositide 3-kinase (PI3K) Vps34 (also known as PIK3C3 in mammals) produces phosphatidylinositol 3-phosphate [PI(3)P] on both early and late endosome membranes to control membrane dynamics. We used Vps34-deficient cells to delineate whether Vps34 has additional roles in endocytic...

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Veröffentlicht in:	Journal of cell science 2016-12, Vol.129 (23), p.4424-4435
Hauptverfasser:	Jaber, Nadia, Mohd-Naim, Noor, Wang, Ziqing, DeLeon, Jennifer L, Kim, Seong, Zhong, Hua, Sheshadri, Namratha, Dou, Zhixun, Edinger, Aimee L, Du, Guangwei, Braga, Vania M M, Zong, Wei-Xing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Biocatalysis Class III Phosphatidylinositol 3-Kinases - metabolism Endocytosis Endosomes - metabolism Endosomes - ultrastructure Fibroblasts - metabolism GTPase-Activating Proteins - metabolism HeLa Cells Humans Lysosomes - metabolism Lysosomes - ultrastructure Mice, Knockout Phosphatidylinositol Phosphates - metabolism Protein Transport rab GTP-Binding Proteins - metabolism rab7 GTP-Binding Proteins TOR Serine-Threonine Kinases - metabolism Vacuoles - metabolism Vacuoles - ultrastructure
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