In Primary Aldosteronism, Mineralocorticoids Influence Exosomal Sodium-Chloride Cotransporter Abundance

Distal tubular sodium retention is a potent driver of hypertension, and the thiazide-sensitive sodium-chloride cotransporter (NCC) has a key role in this process. In humans, factors regulating NCC are unclear, but in animal models, aldosterone is a potent regulator, possibly via effects on plasma po...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2017-01, Vol.28 (1), p.56-63
Hauptverfasser:	Wolley, Martin J, Wu, Aihua, Xu, Shengxin, Gordon, Richard D, Fenton, Robert A, Stowasser, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Brief Communications Exosomes - metabolism Female Humans Hyperaldosteronism - metabolism Male Middle Aged Mineralocorticoids - metabolism Sodium Chloride Symporters - physiology
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