Effect of Cytokine Signaling 3 Gene Polymorphisms in Childhood Obesity
Although polymorphisms in suppressor of cytokine signaling 3 (SOCS3) was reported to be related to obesity, Metabolic syndrome (MS), and type 2 diabetes mellitus in various adult studies, there is a lack of data in children. In this study, we examined eight reported polymorphisms of SOCS3 in obese T...
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| Veröffentlicht in: | Journal of clinical research in pediatric endocrinology 2016-12, Vol.8 (4), p.452-460 |
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| container_title | Journal of clinical research in pediatric endocrinology |
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| creator | Boyraz, Mehmet Yeşilkaya, Ediz Ezgü, Fatih Bideci, Aysun Doğan, Haldun Ulucan, Korkut Cinaz, Peyami |
| description | Although polymorphisms in suppressor of cytokine signaling 3 (SOCS3) was reported to be related to obesity, Metabolic syndrome (MS), and type 2 diabetes mellitus in various adult studies, there is a lack of data in children. In this study, we examined eight reported polymorphisms of SOCS3 in obese Turkish children and adolescent with and without MS and compared the results with that of controls.
One hundred and forty eight obese and 63 age- and sex-matched control subjects were enrolled in the study. Obesity classification was carried out according to body mass index. World Health Organization and National Cholesterol Education Program criteria were used for the diagnosis of MS. Genotyping procedure was carried out by polymerase chain reaction and Sanger sequencing protocol.
The frequency of rs2280148 polymorphism was significantly higher in obese subjects with MS than in the control group, whereas the frequency of rs8064821 polymorphism was significantly higher in obese subjects with MS than in obese children without MS.
The significant associations of certain SOCS3 polymorphisms with obesity parameters in both MS and MS -related insulin resistance, hypertension, and fatty liver suggest that polymorphisms in this gene may play a role in the pathogenesis of MS and also that they can be potentially used as a marker for attenuated or aggressive disease. |
| doi_str_mv | 10.4274/jcrpe.3167 |
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One hundred and forty eight obese and 63 age- and sex-matched control subjects were enrolled in the study. Obesity classification was carried out according to body mass index. World Health Organization and National Cholesterol Education Program criteria were used for the diagnosis of MS. Genotyping procedure was carried out by polymerase chain reaction and Sanger sequencing protocol.
The frequency of rs2280148 polymorphism was significantly higher in obese subjects with MS than in the control group, whereas the frequency of rs8064821 polymorphism was significantly higher in obese subjects with MS than in obese children without MS.
The significant associations of certain SOCS3 polymorphisms with obesity parameters in both MS and MS -related insulin resistance, hypertension, and fatty liver suggest that polymorphisms in this gene may play a role in the pathogenesis of MS and also that they can be potentially used as a marker for attenuated or aggressive disease.</description><identifier>ISSN: 1308-5727</identifier><identifier>EISSN: 1308-5735</identifier><identifier>DOI: 10.4274/jcrpe.3167</identifier><identifier>PMID: 27611604</identifier><language>eng</language><publisher>Turkey: Galenos Yayinevi Tic. Ltd</publisher><subject>Adolescent ; Alleles ; Analysis ; Blood Glucose - analysis ; Body Mass Index ; Cellular signal transduction ; Child ; Cytokines ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - genetics ; Female ; Gene Frequency ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease - genetics ; Genotype ; Humans ; Insulin - blood ; Lipids - blood ; Logistic Models ; Male ; Metabolic Syndrome - blood ; Metabolic Syndrome - complications ; Metabolic Syndrome - genetics ; Obesity in children ; Original ; Pediatric Obesity - blood ; Pediatric Obesity - complications ; Pediatric Obesity - genetics ; Polymorphism, Single Nucleotide ; Risk Factors ; Suppressor of Cytokine Signaling 3 Protein - genetics ; Turkey</subject><ispartof>Journal of clinical research in pediatric endocrinology, 2016-12, Vol.8 (4), p.452-460</ispartof><rights>COPYRIGHT 2016 Galenos Yayinevi Tic. Ltd.</rights><rights>Copyright Galenos Yayinevi Dec 2016</rights><rights>Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-aad62e9086219d40cc4c936a2890461f07538a0038668e1534f4b15f76a9ce623</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198005/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198005/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27611604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boyraz, Mehmet</creatorcontrib><creatorcontrib>Yeşilkaya, Ediz</creatorcontrib><creatorcontrib>Ezgü, Fatih</creatorcontrib><creatorcontrib>Bideci, Aysun</creatorcontrib><creatorcontrib>Doğan, Haldun</creatorcontrib><creatorcontrib>Ulucan, Korkut</creatorcontrib><creatorcontrib>Cinaz, Peyami</creatorcontrib><title>Effect of Cytokine Signaling 3 Gene Polymorphisms in Childhood Obesity</title><title>Journal of clinical research in pediatric endocrinology</title><addtitle>J Clin Res Pediatr Endocrinol</addtitle><description>Although polymorphisms in suppressor of cytokine signaling 3 (SOCS3) was reported to be related to obesity, Metabolic syndrome (MS), and type 2 diabetes mellitus in various adult studies, there is a lack of data in children. In this study, we examined eight reported polymorphisms of SOCS3 in obese Turkish children and adolescent with and without MS and compared the results with that of controls.
One hundred and forty eight obese and 63 age- and sex-matched control subjects were enrolled in the study. Obesity classification was carried out according to body mass index. World Health Organization and National Cholesterol Education Program criteria were used for the diagnosis of MS. Genotyping procedure was carried out by polymerase chain reaction and Sanger sequencing protocol.
The frequency of rs2280148 polymorphism was significantly higher in obese subjects with MS than in the control group, whereas the frequency of rs8064821 polymorphism was significantly higher in obese subjects with MS than in obese children without MS.
The significant associations of certain SOCS3 polymorphisms with obesity parameters in both MS and MS -related insulin resistance, hypertension, and fatty liver suggest that polymorphisms in this gene may play a role in the pathogenesis of MS and also that they can be potentially used as a marker for attenuated or aggressive disease.</description><subject>Adolescent</subject><subject>Alleles</subject><subject>Analysis</subject><subject>Blood Glucose - analysis</subject><subject>Body Mass Index</subject><subject>Cellular signal transduction</subject><subject>Child</subject><subject>Cytokines</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Lipids - blood</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - genetics</subject><subject>Obesity in children</subject><subject>Original</subject><subject>Pediatric Obesity - blood</subject><subject>Pediatric Obesity - complications</subject><subject>Pediatric Obesity - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><subject>Suppressor of Cytokine Signaling 3 Protein - genetics</subject><subject>Turkey</subject><issn>1308-5727</issn><issn>1308-5735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkU1rGzEQhkVpaUKSS39AWeilFOxIq-9LIZh8FAIpJD0LWTuy5e5KrrQu-N9X2yQmKdUcJEbPvBrNi9AHgueslex84_IW5pQI-QYdE4rVjEvK3x7OrTxCZ6VscF2MScz5e3TUSkGIwOwYXV16D25skm8W-zH9DBGa-7CKtg9x1dDmGmrie-r3Q8rbdShDaUJsFuvQd-uUuuZuCSWM-1P0ztu-wNnTfoJ-XF0-LG5mt3fX3xYXtzPHJB1n1naiBY2VaInuGHaOOU2FbZXGTBCPJafKYkyVEAoIp8yzJeFeCqsdiJaeoK-PutvdcoDOQRyz7c02h8HmvUk2mNc3MazNKv02nGiFMa8Cn58Ecvq1gzKaIRQHfW8jpF0xRHEqGcZCVfTTP-gm7XKdzEQxqTXh6gW1sj2YEH2q77pJ1FxUKdliqqe-5_-hanQwBJci-FDzrwq-PBa4nErJ4A9_JNhMxpu_xpvJ-Ap_fDmVA_psM_0DlcWmIw</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Boyraz, Mehmet</creator><creator>Yeşilkaya, Ediz</creator><creator>Ezgü, Fatih</creator><creator>Bideci, Aysun</creator><creator>Doğan, Haldun</creator><creator>Ulucan, Korkut</creator><creator>Cinaz, Peyami</creator><general>Galenos Yayinevi Tic. 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analysis</topic><topic>Body Mass Index</topic><topic>Cellular signal transduction</topic><topic>Child</topic><topic>Cytokines</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Lipids - blood</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - complications</topic><topic>Metabolic Syndrome - genetics</topic><topic>Obesity in children</topic><topic>Original</topic><topic>Pediatric Obesity - blood</topic><topic>Pediatric Obesity - complications</topic><topic>Pediatric Obesity - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><topic>Suppressor of Cytokine Signaling 3 Protein - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical research in pediatric endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boyraz, Mehmet</au><au>Yeşilkaya, Ediz</au><au>Ezgü, Fatih</au><au>Bideci, Aysun</au><au>Doğan, Haldun</au><au>Ulucan, Korkut</au><au>Cinaz, Peyami</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Cytokine Signaling 3 Gene Polymorphisms in Childhood Obesity</atitle><jtitle>Journal of clinical research in pediatric endocrinology</jtitle><addtitle>J Clin Res Pediatr Endocrinol</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>8</volume><issue>4</issue><spage>452</spage><epage>460</epage><pages>452-460</pages><issn>1308-5727</issn><eissn>1308-5735</eissn><abstract>Although polymorphisms in suppressor of cytokine signaling 3 (SOCS3) was reported to be related to obesity, Metabolic syndrome (MS), and type 2 diabetes mellitus in various adult studies, there is a lack of data in children. In this study, we examined eight reported polymorphisms of SOCS3 in obese Turkish children and adolescent with and without MS and compared the results with that of controls.
One hundred and forty eight obese and 63 age- and sex-matched control subjects were enrolled in the study. Obesity classification was carried out according to body mass index. World Health Organization and National Cholesterol Education Program criteria were used for the diagnosis of MS. Genotyping procedure was carried out by polymerase chain reaction and Sanger sequencing protocol.
The frequency of rs2280148 polymorphism was significantly higher in obese subjects with MS than in the control group, whereas the frequency of rs8064821 polymorphism was significantly higher in obese subjects with MS than in obese children without MS.
The significant associations of certain SOCS3 polymorphisms with obesity parameters in both MS and MS -related insulin resistance, hypertension, and fatty liver suggest that polymorphisms in this gene may play a role in the pathogenesis of MS and also that they can be potentially used as a marker for attenuated or aggressive disease.</abstract><cop>Turkey</cop><pub>Galenos Yayinevi Tic. Ltd</pub><pmid>27611604</pmid><doi>10.4274/jcrpe.3167</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adolescent Alleles Analysis Blood Glucose - analysis Body Mass Index Cellular signal transduction Child Cytokines Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Female Gene Frequency Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease - genetics Genotype Humans Insulin - blood Lipids - blood Logistic Models Male Metabolic Syndrome - blood Metabolic Syndrome - complications Metabolic Syndrome - genetics Obesity in children Original Pediatric Obesity - blood Pediatric Obesity - complications Pediatric Obesity - genetics Polymorphism, Single Nucleotide Risk Factors Suppressor of Cytokine Signaling 3 Protein - genetics Turkey |
| title | Effect of Cytokine Signaling 3 Gene Polymorphisms in Childhood Obesity |
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