Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides
Synthetic peptides of 20-25 amino acids were employed in enzyme-linked immunosorbent assays to identify linear epitopes in the external glycoprotein gp46 and the transmembrane glycoprotein gp21 of human T-cell leukemia/lymphotropic viruses type I (HTLV-I) and II (HTLV-II). Ten linear epitopes were i...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1991-07, Vol.88 (13), p.5754-5758 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | HORAL, P HALL, W. W SVENNERHOLM, B LYCKE, J JEANSSON, S RYMO, L KAPLAN, M. H VAHLNE, A |
| description | Synthetic peptides of 20-25 amino acids were employed in enzyme-linked immunosorbent assays to identify linear epitopes in the external glycoprotein gp46 and the transmembrane glycoprotein gp21 of human T-cell leukemia/lymphotropic viruses type I (HTLV-I) and II (HTLV-II). Ten linear epitopes were identified in the HTLV-I glycoproteins, seven in gp46 and three in gp21. Three major linear epitopes were identified in the gp46 of HTLV-II. Peptides representing linear epitopes of gp46 were found to be sensitive and specific for the detection of antibody and permit serological identification and differentiation of HTLV-I and HTLV-II infections. |
| doi_str_mv | 10.1073/pnas.88.13.5754 |
| format | Article |
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Peptides representing linear epitopes of gp46 were found to be sensitive and specific for the detection of antibody and permit serological identification and differentiation of HTLV-I and HTLV-II infections.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.88.13.5754</identifier><identifier>PMID: 1712105</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Acad Sciences</publisher><subject>AIDS/HIV ; Amino Acid Sequence ; Antibody Specificity ; Biological and medical sciences ; Deltaretrovirus Antibodies - immunology ; Deltaretrovirus Antigens - immunology ; env Gene Products, Human Immunodeficiency Virus ; Epitopes ; Fundamental and applied biological sciences. Psychology ; Gene Products, env - immunology ; HTLV-I Infections - immunology ; HTLV-II Infections - immunology ; Human T-lymphotropic virus 1 - immunology ; Human T-lymphotropic virus 2 - immunology ; Humans ; Microbiology ; Molecular Sequence Data ; Retroviridae Proteins, Oncogenic - immunology ; Species Specificity ; Techniques used in virology ; Virology</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1991-07, Vol.88 (13), p.5754-5758</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-f1820e46ada21fe78ff12e64bc639fea270449cd568d2d80fbf0765ddc0099283</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/88/13.cover.gif</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC51956/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC51956/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4954070$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1712105$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HORAL, P</creatorcontrib><creatorcontrib>HALL, W. W</creatorcontrib><creatorcontrib>SVENNERHOLM, B</creatorcontrib><creatorcontrib>LYCKE, J</creatorcontrib><creatorcontrib>JEANSSON, S</creatorcontrib><creatorcontrib>RYMO, L</creatorcontrib><creatorcontrib>KAPLAN, M. H</creatorcontrib><creatorcontrib>VAHLNE, A</creatorcontrib><title>Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Synthetic peptides of 20-25 amino acids were employed in enzyme-linked immunosorbent assays to identify linear epitopes in the external glycoprotein gp46 and the transmembrane glycoprotein gp21 of human T-cell leukemia/lymphotropic viruses type I (HTLV-I) and II (HTLV-II). Ten linear epitopes were identified in the HTLV-I glycoproteins, seven in gp46 and three in gp21. Three major linear epitopes were identified in the gp46 of HTLV-II. Peptides representing linear epitopes of gp46 were found to be sensitive and specific for the detection of antibody and permit serological identification and differentiation of HTLV-I and HTLV-II infections.</description><subject>AIDS/HIV</subject><subject>Amino Acid Sequence</subject><subject>Antibody Specificity</subject><subject>Biological and medical sciences</subject><subject>Deltaretrovirus Antibodies - immunology</subject><subject>Deltaretrovirus Antigens - immunology</subject><subject>env Gene Products, Human Immunodeficiency Virus</subject><subject>Epitopes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Products, env - immunology</subject><subject>HTLV-I Infections - immunology</subject><subject>HTLV-II Infections - immunology</subject><subject>Human T-lymphotropic virus 1 - immunology</subject><subject>Human T-lymphotropic virus 2 - immunology</subject><subject>Humans</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Retroviridae Proteins, Oncogenic - immunology</subject><subject>Species Specificity</subject><subject>Techniques used in virology</subject><subject>Virology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-PFCEQxTtGs46rZ08aDkZPPQs00HSyF7PxzySbeFnPhKGLGZSmsaE3zqfxq0o74-pe9ESF93uvKKqqnhO8JrhtLmLQaS3lmjRr3nL2oFoR3JFasA4_rFYY07aWjLLH1ZOUvmCMOy7xWXVGWkIJ5qvqx6aHkJ11Rmc3BjRalA8R6hTBLLfIuwB6QhBdHiMk5ALKe0A7fzBjnMYMLiS0i0wgHfpSULJk7OdBB3RTG_AeeZi_wuA0unXTnErG0gFtfhmO5QbNyYUdSodQwnNpGyFm10N6Wj2y2id4djrPq8_v391cfayvP33YXL29rg3HJNeWSIqBCd1rSiy00lpCQbCtEU1nQdMWM9aZngvZ015iu7W4FbzvTfmSjsrmvLo85sZ5O0BvyqdM2qs4uUFPBzVqp-4rwe3VbrxVnHRcFPvrk30av82QshpcWobXAcY5KYkFJ6Jj_wWJwI0khBbw4giaaUxpAnv3FoLVsnq1rF5JqUijltUXx4u_R_jDH3dd9FcnXSejvZ10MC7dYazjDLe4YC9P2JL_W73X580_AWVn7zN8z81PM8LSyQ</recordid><startdate>19910701</startdate><enddate>19910701</enddate><creator>HORAL, P</creator><creator>HALL, W. W</creator><creator>SVENNERHOLM, B</creator><creator>LYCKE, J</creator><creator>JEANSSON, S</creator><creator>RYMO, L</creator><creator>KAPLAN, M. H</creator><creator>VAHLNE, A</creator><general>National Acad Sciences</general><general>National Academy of Sciences of the United States of America</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19910701</creationdate><title>Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides</title><author>HORAL, P ; HALL, W. W ; SVENNERHOLM, B ; LYCKE, J ; JEANSSON, S ; RYMO, L ; KAPLAN, M. H ; VAHLNE, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-f1820e46ada21fe78ff12e64bc639fea270449cd568d2d80fbf0765ddc0099283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>AIDS/HIV</topic><topic>Amino Acid Sequence</topic><topic>Antibody Specificity</topic><topic>Biological and medical sciences</topic><topic>Deltaretrovirus Antibodies - immunology</topic><topic>Deltaretrovirus Antigens - immunology</topic><topic>env Gene Products, Human Immunodeficiency Virus</topic><topic>Epitopes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Products, env - immunology</topic><topic>HTLV-I Infections - immunology</topic><topic>HTLV-II Infections - immunology</topic><topic>Human T-lymphotropic virus 1 - immunology</topic><topic>Human T-lymphotropic virus 2 - immunology</topic><topic>Humans</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Retroviridae Proteins, Oncogenic - immunology</topic><topic>Species Specificity</topic><topic>Techniques used in virology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HORAL, P</creatorcontrib><creatorcontrib>HALL, W. W</creatorcontrib><creatorcontrib>SVENNERHOLM, B</creatorcontrib><creatorcontrib>LYCKE, J</creatorcontrib><creatorcontrib>JEANSSON, S</creatorcontrib><creatorcontrib>RYMO, L</creatorcontrib><creatorcontrib>KAPLAN, M. H</creatorcontrib><creatorcontrib>VAHLNE, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HORAL, P</au><au>HALL, W. W</au><au>SVENNERHOLM, B</au><au>LYCKE, J</au><au>JEANSSON, S</au><au>RYMO, L</au><au>KAPLAN, M. H</au><au>VAHLNE, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1991-07-01</date><risdate>1991</risdate><volume>88</volume><issue>13</issue><spage>5754</spage><epage>5758</epage><pages>5754-5758</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Synthetic peptides of 20-25 amino acids were employed in enzyme-linked immunosorbent assays to identify linear epitopes in the external glycoprotein gp46 and the transmembrane glycoprotein gp21 of human T-cell leukemia/lymphotropic viruses type I (HTLV-I) and II (HTLV-II). Ten linear epitopes were identified in the HTLV-I glycoproteins, seven in gp46 and three in gp21. Three major linear epitopes were identified in the gp46 of HTLV-II. Peptides representing linear epitopes of gp46 were found to be sensitive and specific for the detection of antibody and permit serological identification and differentiation of HTLV-I and HTLV-II infections.</abstract><cop>Washington, DC</cop><pub>National Acad Sciences</pub><pmid>1712105</pmid><doi>10.1073/pnas.88.13.5754</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1991-07, Vol.88 (13), p.5754-5758 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | AIDS/HIV Amino Acid Sequence Antibody Specificity Biological and medical sciences Deltaretrovirus Antibodies - immunology Deltaretrovirus Antigens - immunology env Gene Products, Human Immunodeficiency Virus Epitopes Fundamental and applied biological sciences. Psychology Gene Products, env - immunology HTLV-I Infections - immunology HTLV-II Infections - immunology Human T-lymphotropic virus 1 - immunology Human T-lymphotropic virus 2 - immunology Humans Microbiology Molecular Sequence Data Retroviridae Proteins, Oncogenic - immunology Species Specificity Techniques used in virology Virology |
| title | Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides |
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