Lactation Duration and Midlife Atherosclerosis
To evaluate lactation duration in relation to subsequent atherosclerosis in women during midlife. The Coronary Artery Risk Development in Young Adults study is a multicenter prospective cohort that enrolled 2,787 women in 1985-1986 (ages 18-30 years, 52% black, 48% white), of whom 2,014 (72%) attend...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 2015-08, Vol.126 (2), p.381-390 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | Gunderson, Erica P. Quesenberry, Charles P. Ning, Xian Jacobs, David R. Gross, Myron Goff, David C. Pletcher, Mark J. Lewis, Cora E. |
| description | To evaluate lactation duration in relation to subsequent atherosclerosis in women during midlife.
The Coronary Artery Risk Development in Young Adults study is a multicenter prospective cohort that enrolled 2,787 women in 1985-1986 (ages 18-30 years, 52% black, 48% white), of whom 2,014 (72%) attended the 20-year follow-up examination in 2005-2006. We selected 846 women (46% black) without heart disease or diabetes at baseline who delivered one or more times after the baseline evaluation, had cardiometabolic risk factors measured at baseline, and had maximum common carotid intima-media thickness (mm) measured at the 20-year follow-up examination in 2005-2006. Lactation duration was summed across all postbaseline births for each woman and (n, women) categorized as: 0 to less than 1 month (n=262), 1 to less than 6 months (n=210), 6 to less than 10 months (n=169), and 10 months or greater (n=205). Multiple linear regression models estimated mean common carotid intima-media thickness (95% confidence interval) and mean differences among lactation duration groups compared with the 0 to less than 1-month group adjusted for prepregnancy obesity, cardiometabolic status, parity, and other risk factors.
Lactation duration had a graded inverse association with common carotid intima-media thickness; mean differences between 10 months or greater compared with 0 to less than 1 month ranged from -0.062 mm for unadjusted models (P trend |
| doi_str_mv | 10.1097/AOG.0000000000000919 |
| format | Article |
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The Coronary Artery Risk Development in Young Adults study is a multicenter prospective cohort that enrolled 2,787 women in 1985-1986 (ages 18-30 years, 52% black, 48% white), of whom 2,014 (72%) attended the 20-year follow-up examination in 2005-2006. We selected 846 women (46% black) without heart disease or diabetes at baseline who delivered one or more times after the baseline evaluation, had cardiometabolic risk factors measured at baseline, and had maximum common carotid intima-media thickness (mm) measured at the 20-year follow-up examination in 2005-2006. Lactation duration was summed across all postbaseline births for each woman and (n, women) categorized as: 0 to less than 1 month (n=262), 1 to less than 6 months (n=210), 6 to less than 10 months (n=169), and 10 months or greater (n=205). Multiple linear regression models estimated mean common carotid intima-media thickness (95% confidence interval) and mean differences among lactation duration groups compared with the 0 to less than 1-month group adjusted for prepregnancy obesity, cardiometabolic status, parity, and other risk factors.
Lactation duration had a graded inverse association with common carotid intima-media thickness; mean differences between 10 months or greater compared with 0 to less than 1 month ranged from -0.062 mm for unadjusted models (P trend <.001) to -0.029 mm for models fully adjusted for prepregnancy body mass index (BMI) and cardiometabolic risk factors, parity, smoking, and sociodemographics (P trend=.010). Stepwise addition of potential mediators (BMI, systolic blood pressure at the 20-year follow-up examination) modestly attenuated the lactation and common carotid intima-media thickness association to -0.027 and -0.023 mm (P trend=.019 and .054).
Shorter lactation duration is associated with subclinical atherosclerosis independent of prepregnancy cardiometabolic risk factors and traditional risk factors. The magnitude of differences in carotid artery intima-media thickness may represent greater vascular aging. Lactation may have long-term benefits that lower cardiovascular disease risk in women.
II.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1097/AOG.0000000000000919</identifier><identifier>PMID: 26241429</identifier><language>eng</language><publisher>United States: by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Breast Feeding - ethnology ; Breast Feeding - statistics & numerical data ; Carotid Intima-Media Thickness ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - metabolism ; Ethnicity ; Female ; Humans ; Lactation - ethnology ; Lactation - metabolism ; Linear Models ; Longitudinal Studies ; Multivariate Analysis ; Pregnancy ; Prospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; United States - epidemiology</subject><ispartof>Obstetrics and gynecology (New York. 1953), 2015-08, Vol.126 (2), p.381-390</ispartof><rights>by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4534-6435f7d7268397c47bf4dc6d4785faaa968a24dc0cc779be7c0a9fb16ff85a6e3</citedby><cites>FETCH-LOGICAL-c4534-6435f7d7268397c47bf4dc6d4785faaa968a24dc0cc779be7c0a9fb16ff85a6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26241429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gunderson, Erica P.</creatorcontrib><creatorcontrib>Quesenberry, Charles P.</creatorcontrib><creatorcontrib>Ning, Xian</creatorcontrib><creatorcontrib>Jacobs, David R.</creatorcontrib><creatorcontrib>Gross, Myron</creatorcontrib><creatorcontrib>Goff, David C.</creatorcontrib><creatorcontrib>Pletcher, Mark J.</creatorcontrib><creatorcontrib>Lewis, Cora E.</creatorcontrib><title>Lactation Duration and Midlife Atherosclerosis</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>To evaluate lactation duration in relation to subsequent atherosclerosis in women during midlife.
The Coronary Artery Risk Development in Young Adults study is a multicenter prospective cohort that enrolled 2,787 women in 1985-1986 (ages 18-30 years, 52% black, 48% white), of whom 2,014 (72%) attended the 20-year follow-up examination in 2005-2006. We selected 846 women (46% black) without heart disease or diabetes at baseline who delivered one or more times after the baseline evaluation, had cardiometabolic risk factors measured at baseline, and had maximum common carotid intima-media thickness (mm) measured at the 20-year follow-up examination in 2005-2006. Lactation duration was summed across all postbaseline births for each woman and (n, women) categorized as: 0 to less than 1 month (n=262), 1 to less than 6 months (n=210), 6 to less than 10 months (n=169), and 10 months or greater (n=205). Multiple linear regression models estimated mean common carotid intima-media thickness (95% confidence interval) and mean differences among lactation duration groups compared with the 0 to less than 1-month group adjusted for prepregnancy obesity, cardiometabolic status, parity, and other risk factors.
Lactation duration had a graded inverse association with common carotid intima-media thickness; mean differences between 10 months or greater compared with 0 to less than 1 month ranged from -0.062 mm for unadjusted models (P trend <.001) to -0.029 mm for models fully adjusted for prepregnancy body mass index (BMI) and cardiometabolic risk factors, parity, smoking, and sociodemographics (P trend=.010). Stepwise addition of potential mediators (BMI, systolic blood pressure at the 20-year follow-up examination) modestly attenuated the lactation and common carotid intima-media thickness association to -0.027 and -0.023 mm (P trend=.019 and .054).
Shorter lactation duration is associated with subclinical atherosclerosis independent of prepregnancy cardiometabolic risk factors and traditional risk factors. The magnitude of differences in carotid artery intima-media thickness may represent greater vascular aging. Lactation may have long-term benefits that lower cardiovascular disease risk in women.
II.</description><subject>Adult</subject><subject>Breast Feeding - ethnology</subject><subject>Breast Feeding - statistics & numerical data</subject><subject>Carotid Intima-Media Thickness</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - metabolism</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Humans</subject><subject>Lactation - ethnology</subject><subject>Lactation - metabolism</subject><subject>Linear Models</subject><subject>Longitudinal Studies</subject><subject>Multivariate Analysis</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>United States - epidemiology</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkFtPwyAYhonRuDn9B8bs0ptOToVyY7J4mCYzu9HEO0Ip2CprJ7Qu_nuZm3NK4Ps4vN8DvACcIjhCUPCL8WwygrtNILEH-ijjJMGEPO-DPoRYJDyjtAeOQniNGsQEOQQ9zDBFFIs-GE2VblVbNfXwuvPriaqL4UNVuMqa4bgtjW-CdqtYhWNwYJUL5mSTB-Dp9ubx6i6Zzib3V-NpomlKaMIoSS0vOGYZEVxTnltaaFZQnqVWKSVYpnDcgVpzLnLDNVTC5ohZm6WKGTIAl2vuosvnptCmbr1ycuGrufKfslGV_HtSV6V8aT5kigRBJIuA8w3AN--dCa2cV0Eb51Rtmi5IxCGGIvaVlK6lOn4xeGO31yAoV1bLaLX8b3UsO9t94rbox9tf7rJxrfHhzXVL42VplGvLbx7DKUwwRCnM4iqJA1PyBTyWibs</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Gunderson, Erica P.</creator><creator>Quesenberry, Charles P.</creator><creator>Ning, Xian</creator><creator>Jacobs, David R.</creator><creator>Gross, Myron</creator><creator>Goff, David C.</creator><creator>Pletcher, Mark J.</creator><creator>Lewis, Cora E.</creator><general>by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150801</creationdate><title>Lactation Duration and Midlife Atherosclerosis</title><author>Gunderson, Erica P. ; Quesenberry, Charles P. ; Ning, Xian ; Jacobs, David R. ; Gross, Myron ; Goff, David C. ; Pletcher, Mark J. ; Lewis, Cora E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4534-6435f7d7268397c47bf4dc6d4785faaa968a24dc0cc779be7c0a9fb16ff85a6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Breast Feeding - ethnology</topic><topic>Breast Feeding - statistics & numerical data</topic><topic>Carotid Intima-Media Thickness</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - metabolism</topic><topic>Ethnicity</topic><topic>Female</topic><topic>Humans</topic><topic>Lactation - ethnology</topic><topic>Lactation - metabolism</topic><topic>Linear Models</topic><topic>Longitudinal Studies</topic><topic>Multivariate Analysis</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gunderson, Erica P.</creatorcontrib><creatorcontrib>Quesenberry, Charles P.</creatorcontrib><creatorcontrib>Ning, Xian</creatorcontrib><creatorcontrib>Jacobs, David R.</creatorcontrib><creatorcontrib>Gross, Myron</creatorcontrib><creatorcontrib>Goff, David C.</creatorcontrib><creatorcontrib>Pletcher, Mark J.</creatorcontrib><creatorcontrib>Lewis, Cora E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gunderson, Erica P.</au><au>Quesenberry, Charles P.</au><au>Ning, Xian</au><au>Jacobs, David R.</au><au>Gross, Myron</au><au>Goff, David C.</au><au>Pletcher, Mark J.</au><au>Lewis, Cora E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactation Duration and Midlife Atherosclerosis</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>126</volume><issue>2</issue><spage>381</spage><epage>390</epage><pages>381-390</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><abstract>To evaluate lactation duration in relation to subsequent atherosclerosis in women during midlife.
The Coronary Artery Risk Development in Young Adults study is a multicenter prospective cohort that enrolled 2,787 women in 1985-1986 (ages 18-30 years, 52% black, 48% white), of whom 2,014 (72%) attended the 20-year follow-up examination in 2005-2006. We selected 846 women (46% black) without heart disease or diabetes at baseline who delivered one or more times after the baseline evaluation, had cardiometabolic risk factors measured at baseline, and had maximum common carotid intima-media thickness (mm) measured at the 20-year follow-up examination in 2005-2006. Lactation duration was summed across all postbaseline births for each woman and (n, women) categorized as: 0 to less than 1 month (n=262), 1 to less than 6 months (n=210), 6 to less than 10 months (n=169), and 10 months or greater (n=205). Multiple linear regression models estimated mean common carotid intima-media thickness (95% confidence interval) and mean differences among lactation duration groups compared with the 0 to less than 1-month group adjusted for prepregnancy obesity, cardiometabolic status, parity, and other risk factors.
Lactation duration had a graded inverse association with common carotid intima-media thickness; mean differences between 10 months or greater compared with 0 to less than 1 month ranged from -0.062 mm for unadjusted models (P trend <.001) to -0.029 mm for models fully adjusted for prepregnancy body mass index (BMI) and cardiometabolic risk factors, parity, smoking, and sociodemographics (P trend=.010). Stepwise addition of potential mediators (BMI, systolic blood pressure at the 20-year follow-up examination) modestly attenuated the lactation and common carotid intima-media thickness association to -0.027 and -0.023 mm (P trend=.019 and .054).
Shorter lactation duration is associated with subclinical atherosclerosis independent of prepregnancy cardiometabolic risk factors and traditional risk factors. The magnitude of differences in carotid artery intima-media thickness may represent greater vascular aging. Lactation may have long-term benefits that lower cardiovascular disease risk in women.
II.</abstract><cop>United States</cop><pub>by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>26241429</pmid><doi>10.1097/AOG.0000000000000919</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0029-7844 |
| ispartof | Obstetrics and gynecology (New York. 1953), 2015-08, Vol.126 (2), p.381-390 |
| issn | 0029-7844 1873-233X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5193138 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Breast Feeding - ethnology Breast Feeding - statistics & numerical data Carotid Intima-Media Thickness Coronary Artery Disease - diagnosis Coronary Artery Disease - epidemiology Coronary Artery Disease - metabolism Ethnicity Female Humans Lactation - ethnology Lactation - metabolism Linear Models Longitudinal Studies Multivariate Analysis Pregnancy Prospective Studies Risk Assessment Risk Factors Time Factors United States - epidemiology |
| title | Lactation Duration and Midlife Atherosclerosis |
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