MXRA5 is a TGF‐β1‐regulated human protein with anti‐inflammatory and anti‐fibrotic properties

Current therapy for chronic kidney disease (CKD) is unsatisfactory because of an insufficient understanding of its pathogenesis. Matrix remodelling‐associated protein 5 (MXRA5, adlican) is a human protein of unknown function with high kidney tissue expression, not present in rodents. Given the incre...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2017-01, Vol.21 (1), p.154-164
Hauptverfasser:	Poveda, Jonay, Sanz, Ana B., Fernandez‐Fernandez, Beatriz, Carrasco, Susana, Ruiz‐Ortega, Marta, Cannata‐Ortiz, Pablo, Ortiz, Alberto, Sanchez‐Niño, Maria D.
Format:	Artikel
Sprache:	eng
Schlagworte:	adlican Anti-Inflammatory Agents - metabolism Carcinoma, Renal Cell - metabolism Cell Line chronic kidney disease Down-Regulation - drug effects Epithelial Cells - metabolism Ergocalciferols - pharmacology fibrosis Fibrosis - metabolism Humans inflammation Inflammation - metabolism kidney Kidney - metabolism Original perlecan polycystic kidney disease Proteoglycans - metabolism RNA, Messenger - metabolism Signal Transduction - drug effects Transforming Growth Factor beta1 - metabolism Up-Regulation - drug effects Von Hippel-Lindau Tumor Suppressor Protein - metabolism
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