Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets

Liver fibrosis is a reversible wound-healing process aimed at maintaining organ integrity, and presents as the critical pre-stage of liver cirrhosis, which will eventually progress to hepatocellular carcinoma in the absence of liver transplantation. Fibrosis generally results from chronic hepatic in...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2016-12, Vol.22 (48), p.10512-10522
Hauptverfasser:	Zhang, Chong-Yang, Yuan, Wei-Gang, He, Pei, Lei, Jia-Hui, Wang, Chun-Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA C-Acetyltransferase - metabolism Animals CD4-Positive T-Lymphocytes - metabolism Disease Progression Fatty Liver, Alcoholic - complications Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - pathology Humans Interleukins - metabolism Intracellular Signaling Peptides and Proteins - metabolism LIM Domain Proteins - metabolism Liver Cirrhosis - drug therapy Liver Cirrhosis - etiology Liver Cirrhosis - pathology Macrophages - metabolism MicroRNAs - metabolism Molecular Targeted Therapy - methods Non-alcoholic Fatty Liver Disease - complications Resveratrol Review Schistosomiasis - complications Signal Transduction Stilbenes - therapeutic use T-Lymphocytes, Regulatory - metabolism Triterpenes - therapeutic use Ursodeoxycholic Acid - analogs & derivatives Ursodeoxycholic Acid - therapeutic use Ursolic Acid Virus Diseases - complications
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