Sonodynamic inactivation of Gram-positive and Gram-negative bacteria using a Rose Bengal–antimicrobial peptide conjugate

Highlights • Potential use of antimicrobial sonodynamic therapy (ASDT) as antibiotic-free treatment for localised infection. • Broad-spectrum efficacy of ASDT using a sensitiser–antimicrobial peptide hybrid. • In vivo demonstration of ASDT in a murine model of localised infection. • Ability of low-i...

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Veröffentlicht in:	International journal of antimicrobial agents 2017-01, Vol.49 (1), p.31-36
Hauptverfasser:	Costley, David, Nesbitt, Heather, Ternan, Nigel, Dooley, James, Huang, Ying-Ying, Hamblin, Michael R, McHale, Anthony P, Callan, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - pharmacology Antimicrobial Antimicrobial Cationic Peptides - pharmacology Bacterial Load Disease Models, Animal Disinfection - methods Fluorescent Dyes - pharmacology Infectious Disease Mice, Inbred BALB C Peptide Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - radiation effects Rose Bengal - pharmacology Sensitiser Sonodynamic therapy Staphylococcus aureus - drug effects Staphylococcus aureus - radiation effects Ultrasonic Waves Wound Infection - drug therapy Wound Infection - microbiology
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Zusammenfassung:	Highlights • Potential use of antimicrobial sonodynamic therapy (ASDT) as antibiotic-free treatment for localised infection. • Broad-spectrum efficacy of ASDT using a sensitiser–antimicrobial peptide hybrid. • In vivo demonstration of ASDT in a murine model of localised infection. • Ability of low-intensity ultrasound to enhance uptake of sensitisers in bacterial biofilms.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2016.09.034