Mre11 deficiency in Arabidopsis is associated with chromosomal instability in somatic cells and Spo11-dependent genome fragmentation during meiosis
The Mre11/Rad50/Nbs1 complex is involved in many aspects of chromosome metabolism. Aberrant function of the complex is associated with defects in the DNA checkpoint, double-strand break repair, meiosis, and telomere maintenance. In this article, we report the consequences of Mre11 dysfunction for th...
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| Veröffentlicht in: | The Plant cell 2004-08, Vol.16 (8), p.1968-1978 |
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| container_end_page | 1978 |
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| container_issue | 8 |
| container_start_page | 1968 |
| container_title | The Plant cell |
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| creator | Puizina, J Siroky, J Mokros, P Schweizer, D Riha, K |
| description | The Mre11/Rad50/Nbs1 complex is involved in many aspects of chromosome metabolism. Aberrant function of the complex is associated with defects in the DNA checkpoint, double-strand break repair, meiosis, and telomere maintenance. In this article, we report the consequences of Mre11 dysfunction for the stability of mitotic and meiotic chromosomes in Arabidopsis thaliana. Although plants homozygous for a T-DNA insertion in a conserved region of the MRE11 gene are viable, they exhibit growth defects and are infertile. Analysis of mitotic chromosomes prepared from the mutant plants revealed abundant dicentric chromosomes and chromosomal fragments. Fluorescence in situ hybridization showed that anaphase bridges are often formed by homologous chromosome arms. The frequency of chromosome fusions was not reduced in mre11 ku70 double mutants, suggesting that plants possess DNA end-joining activities independent of the Ku70/80 and Mre11 complexes. Cytogenetic examination of pollen mother cells revealed massive chromosome fragmentation and the absence of synapsis in the initial stages of meiosis. The fragmentation was substantially suppressed in mre11 spo11-1 double mutants, indicating that Mre11 is required for repair but not for the induction of Spo11-dependent meiotic DNA breaks in Arabidopsis. |
| doi_str_mv | 10.1105/tpc.104.022749 |
| format | Article |
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Aberrant function of the complex is associated with defects in the DNA checkpoint, double-strand break repair, meiosis, and telomere maintenance. In this article, we report the consequences of Mre11 dysfunction for the stability of mitotic and meiotic chromosomes in Arabidopsis thaliana. Although plants homozygous for a T-DNA insertion in a conserved region of the MRE11 gene are viable, they exhibit growth defects and are infertile. Analysis of mitotic chromosomes prepared from the mutant plants revealed abundant dicentric chromosomes and chromosomal fragments. Fluorescence in situ hybridization showed that anaphase bridges are often formed by homologous chromosome arms. The frequency of chromosome fusions was not reduced in mre11 ku70 double mutants, suggesting that plants possess DNA end-joining activities independent of the Ku70/80 and Mre11 complexes. Cytogenetic examination of pollen mother cells revealed massive chromosome fragmentation and the absence of synapsis in the initial stages of meiosis. The fragmentation was substantially suppressed in mre11 spo11-1 double mutants, indicating that Mre11 is required for repair but not for the induction of Spo11-dependent meiotic DNA breaks in Arabidopsis.</description><identifier>ISSN: 1040-4651</identifier><identifier>EISSN: 1532-298X</identifier><identifier>DOI: 10.1105/tpc.104.022749</identifier><identifier>PMID: 15258261</identifier><language>eng</language><publisher>United States: American Society of Plant Biologists</publisher><subject>Alleles ; Amino Acid Sequence ; Anaphase ; Animals ; Arabidopsis ; Arabidopsis - anatomy & histology ; Arabidopsis - genetics ; Arabidopsis - physiology ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Arabidopsis thaliana ; Base Sequence ; Chromosomal Instability ; chromosome aberrations ; chromosome breakage ; chromosome pairing ; Chromosomes ; Chromosomes, Plant - metabolism ; cytogenetics ; Deoxyribonucleic acid ; DNA ; DNA Fragmentation ; DNA repair ; DNA-binding proteins ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Endodeoxyribonucleases ; Esterases - metabolism ; gametogenesis ; gene expression ; Genes ; genetic recombination ; genetic stability ; Genomes ; Humans ; In Situ Hybridization, Fluorescence ; Macromolecular Substances ; Meiosis ; Meiosis - physiology ; messenger RNA ; Molecular Sequence Data ; MRE11 Homologue Protein ; mutants ; mutation ; phenotype ; plant fertility ; Plants ; Pollen ; pollen mother cells ; Recombination, Genetic ; Telomeres</subject><ispartof>The Plant cell, 2004-08, Vol.16 (8), p.1968-1978</ispartof><rights>Copyright 2004 American Society of Plant Biologists</rights><rights>Copyright American Society of Plant Physiologists Aug 2004</rights><rights>Copyright © 2004, American Society of Plant Biologists 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-de81da046842f83f7059d65750122cb84887b5f2769f3c2aa1fe061d206203ac3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3872320$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3872320$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15258261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Puizina, J</creatorcontrib><creatorcontrib>Siroky, J</creatorcontrib><creatorcontrib>Mokros, P</creatorcontrib><creatorcontrib>Schweizer, D</creatorcontrib><creatorcontrib>Riha, K</creatorcontrib><title>Mre11 deficiency in Arabidopsis is associated with chromosomal instability in somatic cells and Spo11-dependent genome fragmentation during meiosis</title><title>The Plant cell</title><addtitle>Plant Cell</addtitle><description>The Mre11/Rad50/Nbs1 complex is involved in many aspects of chromosome metabolism. Aberrant function of the complex is associated with defects in the DNA checkpoint, double-strand break repair, meiosis, and telomere maintenance. In this article, we report the consequences of Mre11 dysfunction for the stability of mitotic and meiotic chromosomes in Arabidopsis thaliana. Although plants homozygous for a T-DNA insertion in a conserved region of the MRE11 gene are viable, they exhibit growth defects and are infertile. Analysis of mitotic chromosomes prepared from the mutant plants revealed abundant dicentric chromosomes and chromosomal fragments. Fluorescence in situ hybridization showed that anaphase bridges are often formed by homologous chromosome arms. The frequency of chromosome fusions was not reduced in mre11 ku70 double mutants, suggesting that plants possess DNA end-joining activities independent of the Ku70/80 and Mre11 complexes. Cytogenetic examination of pollen mother cells revealed massive chromosome fragmentation and the absence of synapsis in the initial stages of meiosis. The fragmentation was substantially suppressed in mre11 spo11-1 double mutants, indicating that Mre11 is required for repair but not for the induction of Spo11-dependent meiotic DNA breaks in Arabidopsis.</description><subject>Alleles</subject><subject>Amino Acid Sequence</subject><subject>Anaphase</subject><subject>Animals</subject><subject>Arabidopsis</subject><subject>Arabidopsis - anatomy & histology</subject><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - physiology</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Arabidopsis thaliana</subject><subject>Base Sequence</subject><subject>Chromosomal Instability</subject><subject>chromosome aberrations</subject><subject>chromosome breakage</subject><subject>chromosome pairing</subject><subject>Chromosomes</subject><subject>Chromosomes, Plant - metabolism</subject><subject>cytogenetics</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Fragmentation</subject><subject>DNA repair</subject><subject>DNA-binding proteins</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Endodeoxyribonucleases</subject><subject>Esterases - metabolism</subject><subject>gametogenesis</subject><subject>gene expression</subject><subject>Genes</subject><subject>genetic recombination</subject><subject>genetic stability</subject><subject>Genomes</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Macromolecular Substances</subject><subject>Meiosis</subject><subject>Meiosis - physiology</subject><subject>messenger RNA</subject><subject>Molecular Sequence Data</subject><subject>MRE11 Homologue Protein</subject><subject>mutants</subject><subject>mutation</subject><subject>phenotype</subject><subject>plant fertility</subject><subject>Plants</subject><subject>Pollen</subject><subject>pollen mother cells</subject><subject>Recombination, Genetic</subject><subject>Telomeres</subject><issn>1040-4651</issn><issn>1532-298X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkktv1DAQxyMEomXhygmBxYHbLjOOHTuHHqqKFqQiDqUSN8trO7teJXaws6B-Dr4wDrsqjwuSJT_m95-Xp6qeI6wQgb-dRrNCYCugVLD2QXWKvKZL2sovD8sZGCxZw_GkepLzDgBQYPu4OkFOuaQNnlY_PiaHSKzrvPEumDviAzlPeu1tHLPPpCydczReT86S737aErNNcYg5DrovdJ4K3Pvpl3J-nLwhxvV9EQZLbsaIuLRudMG6MJGNC3FwpEt6M5R7oWMgdp982JDB-VhiPq0edbrP7tlxX1S3l-8-X7xfXn-6-nBxfr00nOJUfEq0GlgjGe1k3QngrW244ICUmrVkUoo176ho2q42VGvsHDRoKTQUam3qRXV28Dvu14OzpqSTdK_G5Aed7lTUXv1tCX6rNvGb4tiibIv-zVGf4te9y5MafJ4r18HFfVZNU0KXj_kviEJASxtewNf_gLu4T6E0QVGUQggGc9jVATIp5pxcd58xgpqHQpWhKGemDkNRBC__rPM3fpyCArw4ALs8xXRvr6WgdWnVonp1MHc6Kr1JPqvbGwpYA7SMzSn9BFm9yCI</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Puizina, J</creator><creator>Siroky, J</creator><creator>Mokros, P</creator><creator>Schweizer, D</creator><creator>Riha, K</creator><general>American Society of Plant Biologists</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7QO</scope><scope>7TM</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20040801</creationdate><title>Mre11 deficiency in Arabidopsis is associated with chromosomal instability in somatic cells and Spo11-dependent genome fragmentation during meiosis</title><author>Puizina, J ; Siroky, J ; Mokros, P ; Schweizer, D ; Riha, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-de81da046842f83f7059d65750122cb84887b5f2769f3c2aa1fe061d206203ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Alleles</topic><topic>Amino Acid Sequence</topic><topic>Anaphase</topic><topic>Animals</topic><topic>Arabidopsis</topic><topic>Arabidopsis - anatomy & histology</topic><topic>Arabidopsis - genetics</topic><topic>Arabidopsis - physiology</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>Arabidopsis thaliana</topic><topic>Base Sequence</topic><topic>Chromosomal Instability</topic><topic>chromosome aberrations</topic><topic>chromosome breakage</topic><topic>chromosome pairing</topic><topic>Chromosomes</topic><topic>Chromosomes, Plant - metabolism</topic><topic>cytogenetics</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Fragmentation</topic><topic>DNA repair</topic><topic>DNA-binding proteins</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Endodeoxyribonucleases</topic><topic>Esterases - metabolism</topic><topic>gametogenesis</topic><topic>gene expression</topic><topic>Genes</topic><topic>genetic recombination</topic><topic>genetic stability</topic><topic>Genomes</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Macromolecular Substances</topic><topic>Meiosis</topic><topic>Meiosis - physiology</topic><topic>messenger RNA</topic><topic>Molecular Sequence Data</topic><topic>MRE11 Homologue Protein</topic><topic>mutants</topic><topic>mutation</topic><topic>phenotype</topic><topic>plant fertility</topic><topic>Plants</topic><topic>Pollen</topic><topic>pollen mother cells</topic><topic>Recombination, Genetic</topic><topic>Telomeres</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Puizina, J</creatorcontrib><creatorcontrib>Siroky, J</creatorcontrib><creatorcontrib>Mokros, P</creatorcontrib><creatorcontrib>Schweizer, D</creatorcontrib><creatorcontrib>Riha, K</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Plant cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Puizina, J</au><au>Siroky, J</au><au>Mokros, P</au><au>Schweizer, D</au><au>Riha, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mre11 deficiency in Arabidopsis is associated with chromosomal instability in somatic cells and Spo11-dependent genome fragmentation during meiosis</atitle><jtitle>The Plant cell</jtitle><addtitle>Plant Cell</addtitle><date>2004-08-01</date><risdate>2004</risdate><volume>16</volume><issue>8</issue><spage>1968</spage><epage>1978</epage><pages>1968-1978</pages><issn>1040-4651</issn><eissn>1532-298X</eissn><abstract>The Mre11/Rad50/Nbs1 complex is involved in many aspects of chromosome metabolism. Aberrant function of the complex is associated with defects in the DNA checkpoint, double-strand break repair, meiosis, and telomere maintenance. In this article, we report the consequences of Mre11 dysfunction for the stability of mitotic and meiotic chromosomes in Arabidopsis thaliana. Although plants homozygous for a T-DNA insertion in a conserved region of the MRE11 gene are viable, they exhibit growth defects and are infertile. Analysis of mitotic chromosomes prepared from the mutant plants revealed abundant dicentric chromosomes and chromosomal fragments. Fluorescence in situ hybridization showed that anaphase bridges are often formed by homologous chromosome arms. The frequency of chromosome fusions was not reduced in mre11 ku70 double mutants, suggesting that plants possess DNA end-joining activities independent of the Ku70/80 and Mre11 complexes. Cytogenetic examination of pollen mother cells revealed massive chromosome fragmentation and the absence of synapsis in the initial stages of meiosis. The fragmentation was substantially suppressed in mre11 spo11-1 double mutants, indicating that Mre11 is required for repair but not for the induction of Spo11-dependent meiotic DNA breaks in Arabidopsis.</abstract><cop>United States</cop><pub>American Society of Plant Biologists</pub><pmid>15258261</pmid><doi>10.1105/tpc.104.022749</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Plant cell, 2004-08, Vol.16 (8), p.1968-1978 |
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| subjects | Alleles Amino Acid Sequence Anaphase Animals Arabidopsis Arabidopsis - anatomy & histology Arabidopsis - genetics Arabidopsis - physiology Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Arabidopsis thaliana Base Sequence Chromosomal Instability chromosome aberrations chromosome breakage chromosome pairing Chromosomes Chromosomes, Plant - metabolism cytogenetics Deoxyribonucleic acid DNA DNA Fragmentation DNA repair DNA-binding proteins DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endodeoxyribonucleases Esterases - metabolism gametogenesis gene expression Genes genetic recombination genetic stability Genomes Humans In Situ Hybridization, Fluorescence Macromolecular Substances Meiosis Meiosis - physiology messenger RNA Molecular Sequence Data MRE11 Homologue Protein mutants mutation phenotype plant fertility Plants Pollen pollen mother cells Recombination, Genetic Telomeres |
| title | Mre11 deficiency in Arabidopsis is associated with chromosomal instability in somatic cells and Spo11-dependent genome fragmentation during meiosis |
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