Length regulation and dynamics of individual telomere tracts in wild-type Arabidopsis
Although length of the telomeric DNA tract varies widely across evolution, a species-specific set point is established and maintained by unknown mechanisms. To investigate how telomere length is controlled in Arabidopsis thaliana, we analyzed bulk telomere length in 14 wild-type accessions. We found...
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| Veröffentlicht in: | The Plant cell 2004-08, Vol.16 (8), p.1959-1967 |
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| container_end_page | 1967 |
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| container_issue | 8 |
| container_start_page | 1959 |
| container_title | The Plant cell |
| container_volume | 16 |
| creator | Shakirov, E.V Shippen, D.E |
| description | Although length of the telomeric DNA tract varies widely across evolution, a species-specific set point is established and maintained by unknown mechanisms. To investigate how telomere length is controlled in Arabidopsis thaliana, we analyzed bulk telomere length in 14 wild-type accessions. We found that telomere tracts in Arabidopsis are fairly uniformly distributed throughout a size range of 2 to 9 kb. Unexpectedly, telomeres in plants of the Wassilewskija ecotype displayed a bimodal size distribution, with some individuals harboring telomeres of 2 to 5 kb and others telomeres of 4 to 9 kb. F1 and F2 progeny of a cross between long and short telomere parents had intermediate telomeres, implying that telomere length in Arabidopsis is not controlled by a single genetic factor. We provide evidence that although global telomere length is strictly regulated within an ecotype-specific range, telomere tracts on individual chromosome ends do not occupy a predetermined length territory. We also demonstrate that individual telomere tracts on homologous chromosomes are coordinately regulated throughout development and that telomerase acts preferentially on the shortest telomeres. We propose that an optimal size for telomere tracts is established and maintained for each Arabidopsis ecotype. |
| doi_str_mv | 10.1105/tpc.104.023093 |
| format | Article |
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To investigate how telomere length is controlled in Arabidopsis thaliana, we analyzed bulk telomere length in 14 wild-type accessions. We found that telomere tracts in Arabidopsis are fairly uniformly distributed throughout a size range of 2 to 9 kb. Unexpectedly, telomeres in plants of the Wassilewskija ecotype displayed a bimodal size distribution, with some individuals harboring telomeres of 2 to 5 kb and others telomeres of 4 to 9 kb. F1 and F2 progeny of a cross between long and short telomere parents had intermediate telomeres, implying that telomere length in Arabidopsis is not controlled by a single genetic factor. We provide evidence that although global telomere length is strictly regulated within an ecotype-specific range, telomere tracts on individual chromosome ends do not occupy a predetermined length territory. We also demonstrate that individual telomere tracts on homologous chromosomes are coordinately regulated throughout development and that telomerase acts preferentially on the shortest telomeres. We propose that an optimal size for telomere tracts is established and maintained for each Arabidopsis ecotype.</description><identifier>ISSN: 1040-4651</identifier><identifier>EISSN: 1532-298X</identifier><identifier>DOI: 10.1105/tpc.104.023093</identifier><identifier>PMID: 15258263</identifier><language>eng</language><publisher>United States: American Society of Plant Biologists</publisher><subject>Animals ; Arabidopsis - genetics ; Arabidopsis - metabolism ; Arabidopsis thaliana ; Chromosomes ; cytogenetics ; DNA ; DNA probes ; DNA, Plant - analysis ; Ecosystem ; ecotype-specific telomere length ; ecotypes ; enzyme activity ; Evolution, Molecular ; Gene expression regulation ; Genetic Variation ; homologous chromosomes ; Humans ; length ; Mendelian inheritance ; Plant cells ; Random Allocation ; Siblings ; Size distribution ; telomerase ; Telomere - genetics ; Telomere - metabolism ; telomere length variation ; telomere tracts ; Telomeres</subject><ispartof>The Plant cell, 2004-08, Vol.16 (8), p.1959-1967</ispartof><rights>Copyright 2004 American Society of Plant Biologists</rights><rights>Copyright American Society of Plant Physiologists Aug 2004</rights><rights>Copyright © 2004, American Society of Plant Biologists 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c587t-bff18f9e0c162842537f45207a0c5560396db904cc75d1485f99964178ec17cb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3872319$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3872319$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15258263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shakirov, E.V</creatorcontrib><creatorcontrib>Shippen, D.E</creatorcontrib><title>Length regulation and dynamics of individual telomere tracts in wild-type Arabidopsis</title><title>The Plant cell</title><addtitle>Plant Cell</addtitle><description>Although length of the telomeric DNA tract varies widely across evolution, a species-specific set point is established and maintained by unknown mechanisms. To investigate how telomere length is controlled in Arabidopsis thaliana, we analyzed bulk telomere length in 14 wild-type accessions. We found that telomere tracts in Arabidopsis are fairly uniformly distributed throughout a size range of 2 to 9 kb. Unexpectedly, telomeres in plants of the Wassilewskija ecotype displayed a bimodal size distribution, with some individuals harboring telomeres of 2 to 5 kb and others telomeres of 4 to 9 kb. F1 and F2 progeny of a cross between long and short telomere parents had intermediate telomeres, implying that telomere length in Arabidopsis is not controlled by a single genetic factor. We provide evidence that although global telomere length is strictly regulated within an ecotype-specific range, telomere tracts on individual chromosome ends do not occupy a predetermined length territory. We also demonstrate that individual telomere tracts on homologous chromosomes are coordinately regulated throughout development and that telomerase acts preferentially on the shortest telomeres. We propose that an optimal size for telomere tracts is established and maintained for each Arabidopsis ecotype.</description><subject>Animals</subject><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - metabolism</subject><subject>Arabidopsis thaliana</subject><subject>Chromosomes</subject><subject>cytogenetics</subject><subject>DNA</subject><subject>DNA probes</subject><subject>DNA, Plant - analysis</subject><subject>Ecosystem</subject><subject>ecotype-specific telomere length</subject><subject>ecotypes</subject><subject>enzyme activity</subject><subject>Evolution, Molecular</subject><subject>Gene expression regulation</subject><subject>Genetic Variation</subject><subject>homologous chromosomes</subject><subject>Humans</subject><subject>length</subject><subject>Mendelian inheritance</subject><subject>Plant cells</subject><subject>Random Allocation</subject><subject>Siblings</subject><subject>Size distribution</subject><subject>telomerase</subject><subject>Telomere - genetics</subject><subject>Telomere - metabolism</subject><subject>telomere length variation</subject><subject>telomere tracts</subject><subject>Telomeres</subject><issn>1040-4651</issn><issn>1532-298X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkbuP1DAQxiME4h7QUiGIKOiyzPjtguJ04gBpJQpYic7yOs6eV0kc7OTQ_vf4tKvj0VB5pO_3jWfmq6oXCCtE4O_mya0Q2AoIBU0fVefIKWmIVt8flxoYNExwPKsuct4DAErUT6sz5IQrIuh5tVn7cTff1snvlt7OIY61Hdu6PYx2CC7XsavD2Ia70C62r2ffx8EnX8_JujkXqf4Z-raZD5Ovr5LdhjZOOeRn1ZPO9tk_P72X1ebmw7frT836y8fP11frxnEl52bbdag67cGhIIoRTmXHOAFpwXEugGrRbjUw5yRvkSneaa0FQ6m8Q-m29LJ6f-w7LdvBt86PZbDeTCkMNh1MtMH8rYzh1uzineGoUanif3vyp_hj8Xk2Q8jO970dfVyyEUIKRTX_L4hSghRIC_jmH3AflzSWIxiCqlBc3H-7OkIuxZyT7x4mRjD3sZoSa6mZOcZaDK_-3PM3fsqxAC-PwD7PMT3oVElCURf59VHubDR2l0I2m68EkAJoxhhw-guTJrEc</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Shakirov, E.V</creator><creator>Shippen, D.E</creator><general>American Society of Plant Biologists</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7QO</scope><scope>7TM</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20040801</creationdate><title>Length regulation and dynamics of individual telomere tracts in wild-type Arabidopsis</title><author>Shakirov, E.V ; Shippen, D.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c587t-bff18f9e0c162842537f45207a0c5560396db904cc75d1485f99964178ec17cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Arabidopsis - genetics</topic><topic>Arabidopsis - metabolism</topic><topic>Arabidopsis thaliana</topic><topic>Chromosomes</topic><topic>cytogenetics</topic><topic>DNA</topic><topic>DNA probes</topic><topic>DNA, Plant - analysis</topic><topic>Ecosystem</topic><topic>ecotype-specific telomere length</topic><topic>ecotypes</topic><topic>enzyme activity</topic><topic>Evolution, Molecular</topic><topic>Gene expression regulation</topic><topic>Genetic Variation</topic><topic>homologous chromosomes</topic><topic>Humans</topic><topic>length</topic><topic>Mendelian inheritance</topic><topic>Plant cells</topic><topic>Random Allocation</topic><topic>Siblings</topic><topic>Size distribution</topic><topic>telomerase</topic><topic>Telomere - genetics</topic><topic>Telomere - metabolism</topic><topic>telomere length variation</topic><topic>telomere tracts</topic><topic>Telomeres</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shakirov, E.V</creatorcontrib><creatorcontrib>Shippen, D.E</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - 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To investigate how telomere length is controlled in Arabidopsis thaliana, we analyzed bulk telomere length in 14 wild-type accessions. We found that telomere tracts in Arabidopsis are fairly uniformly distributed throughout a size range of 2 to 9 kb. Unexpectedly, telomeres in plants of the Wassilewskija ecotype displayed a bimodal size distribution, with some individuals harboring telomeres of 2 to 5 kb and others telomeres of 4 to 9 kb. F1 and F2 progeny of a cross between long and short telomere parents had intermediate telomeres, implying that telomere length in Arabidopsis is not controlled by a single genetic factor. We provide evidence that although global telomere length is strictly regulated within an ecotype-specific range, telomere tracts on individual chromosome ends do not occupy a predetermined length territory. 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| ispartof | The Plant cell, 2004-08, Vol.16 (8), p.1959-1967 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animals Arabidopsis - genetics Arabidopsis - metabolism Arabidopsis thaliana Chromosomes cytogenetics DNA DNA probes DNA, Plant - analysis Ecosystem ecotype-specific telomere length ecotypes enzyme activity Evolution, Molecular Gene expression regulation Genetic Variation homologous chromosomes Humans length Mendelian inheritance Plant cells Random Allocation Siblings Size distribution telomerase Telomere - genetics Telomere - metabolism telomere length variation telomere tracts Telomeres |
| title | Length regulation and dynamics of individual telomere tracts in wild-type Arabidopsis |
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