Redox-sensitive MAPK and Notch3 regulate fibroblast differentiation and activation: a dual role of ERK1/2

Myofibroblastic transformation, characterized by upregulation of α-smooth muscle actin in response to proï¬brotic agents such as TGF-β1, is considered as a major event leading to ï¬brosis. The mechanistic basis linking myoï¬broblast differentiation to idiopathic pulmonary ï¬brosis and the diseas...

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Veröffentlicht in:	Oncotarget 2016-07, Vol.7 (28), p.43731-43745
Hauptverfasser:	Lai, Jun-Mei, Zhang, Xiong, Liu, Fang-Fang, Yang, Rui, Li, Shen-Yu, Zhu, Lan-Bing, Zou, Ming, Cheng, Wen-Hsing, Zhu, Jian-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - physiology Cell Line Extracellular Signal-Regulated MAP Kinases - metabolism Fibroblasts - metabolism Fibroblasts - pathology Humans Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - pathology Male Mice, Inbred C57BL Myofibroblasts - metabolism Myofibroblasts - pathology Oxidation-Reduction Receptor, Notch3 - metabolism Research Paper Signal Transduction
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