(-)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma

We explored the anti-cancer capacity of (-)-oleocanthal in human hepatocellular carcinoma (HCC). (-)-Oleocanthal inhibited proliferation and cell cycle progression and induced apoptosis in HCC cells in vitro and suppressed tumor growth in an orthotopic HCC model. (-)-Oleocanthal also inhibited HCC c...

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Veröffentlicht in:	Oncotarget 2016-07, Vol.7 (28), p.43475-43491
Hauptverfasser:	Pei, Tiemin, Meng, Qinghui, Han, Jihua, Sun, Haobo, Li, Long, Song, Ruipeng, Sun, Boshi, Pan, Shangha, Liang, Desen, Liu, Lianxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - isolation & purification Aldehydes - therapeutic use Animals Antineoplastic Agents - therapeutic use Apoptosis - drug effects Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Cell Cycle - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Nucleus - metabolism Cell Proliferation - drug effects Cyclin D1 - metabolism Down-Regulation Epithelial-Mesenchymal Transition - drug effects Humans Inhibitor of Apoptosis Proteins - metabolism Janus Kinase 1 - metabolism Janus Kinase 2 - metabolism Liver Neoplasms - drug therapy Liver Neoplasms - pathology Lung Neoplasms - prevention & control Lung Neoplasms - secondary Male Mice, Inbred BALB C Mice, Nude Neoplasm Invasiveness - prevention & control Nuclear Proteins - metabolism Olive Oil - chemistry Phenols - isolation & purification Phenols - therapeutic use Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-bcl-2 - metabolism Research Paper STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Survivin Twist-Related Protein 1 - metabolism Xenograft Model Antitumor Assays
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