NF-κB-Mediated Repression of Growth Arrest- and DNA-Damage-Inducible Proteins 45α and γ Is Essential for Cancer Cell Survival

The NF-κB/IκB signaling pathway is a critical regulator of cell survival in cancer. Here, we report that combined down-regulation of growth arrest- and DNA-damage-inducible proteins (GADD)45α and γ expression by NF-κB is an essential step for various cancer types to escape programmed cell death. We...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-09, Vol.101 (37), p.13618-13623
Hauptverfasser:	Zerbini, Luiz F., Wang, Yihong, Czibere, Akos, Correa, Ricardo G., Cho, Je-Yoel, Ijiri, Kosei, Wei, Wanjang, Joseph, Marie, Gu, Xuesong, Grall, Franck, Goldring, Mary B., Zhou, Jin-Rhong, Libermann, Towia A., Glimcher, Laurie H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological Sciences Cancer Cell growth Cell lines Family members Infections Proteins Small interfering RNA T lymphocytes Transfection
Online-Zugang:	Volltext
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