Alteration of platelet GPVI signaling in ST-elevation myocardial infarction patients demonstrated by a combination of proteomic, biochemical, and functional approaches

The platelet-specific collagen receptor glycoprotein VI (GPVI) is critical for the formation of arterial thrombosis in vivo . We analyzed GPVI-activated platelets from ST-elevation myocardial infarction (STEMI) patients and matched stable coronary artery disease (SCAD) controls in order to provide n...

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Veröffentlicht in:	Scientific reports 2016-12, Vol.6 (1), p.39603-39603, Article 39603
Hauptverfasser:	Vélez, Paula, Ocaranza-Sánchez, Raymundo, López-Otero, Diego, Grigorian-Shamagian, Lilian, Rosa, Isaac, Guitián, Esteban, García-Acuña, José María, González-Juanatey, José Ramón, García, Ángel
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/475 631/80/86 692/4019 82 82/29 82/58 96 96/1 Blood Blood platelets Cardiovascular disease Collagen Coronary artery Coronary vessels Functional anatomy Glycoprotein VI Heart attacks Heart diseases Humanities and Social Sciences Immunoblotting multidisciplinary Myocardial infarction Occlusion Phosphorylation Platelet aggregation Platelets Science SLP-76 protein Thromboembolism Thrombosis Tyrosine
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