Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential

Along with a growing interest in mRNA-based gene therapies, efforts are increasingly focused on reaching the full translational potential of mRNA, as a major obstacle for in vivo applications is sufficient expression of exogenously delivered mRNA. One method to overcome this limitation is chemically...

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Veröffentlicht in:	Nucleic acids research 2016-11, Vol.44 (20), p.9578-9590
Hauptverfasser:	Strenkowska, Malwina, Grzela, Renata, Majewski, Maciej, Wnek, Katarzyna, Kowalska, Joanna, Lukaszewicz, Maciej, Zuberek, Joanna, Darzynkiewicz, Edward, Kuhn, Andreas N, Sahin, Ugur, Jemielity, Jacek
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Biology and Nucleic Acid Chemistry Dendritic Cells Diphosphates - chemistry DNA-Binding Proteins - metabolism Humans Molecular Structure Protein Binding Protein Biosynthesis RNA Cap Analogs - chemical synthesis RNA Caps RNA, Messenger - chemistry RNA, Messenger - genetics Transcription Factors - metabolism
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