Altered glutamine metabolism in platinum resistant ovarian cancer

Ovarian cancer is characterized by an increase in cellular energy metabolism, which is predominantly satisfied by glucose and glutamine. Targeting metabolic pathways is an attractive approach to enhance the therapeutic effectiveness and to potentially overcome drug resistance in ovarian cancer. In p...

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Veröffentlicht in:	Oncotarget 2016-07, Vol.7 (27), p.41637-41649
Hauptverfasser:	Hudson, Chantelle D, Savadelis, Alyssa, Nagaraj, Anil Belur, Joseph, Peronne, Avril, Stefanie, DiFeo, Analisa, Avril, Norbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Cell Line, Tumor Cisplatin - therapeutic use Drug Resistance, Neoplasm Female Glutaminase - metabolism Glutamine - metabolism Humans Metabolic Networks and Pathways - physiology Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Proteome - analysis Proteome - drug effects Research Paper
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