Deubiquitination and Stabilization of PD-L1 by CSN5

Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillanc...

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Veröffentlicht in:	Cancer cell 2016-12, Vol.30 (6), p.925-939
Hauptverfasser:	Lim, Seung-Oe, Li, Chia-Wei, Xia, Weiya, Cha, Jong-Ho, Chan, Li-Chuan, Wu, Yun, Chang, Shih-Shin, Lin, Wan-Chi, Hsu, Jung-Mao, Hsu, Yi-Hsin, Kim, Taewan, Chang, Wei-Chao, Hsu, Jennifer L., Yamaguchi, Hirohito, Ding, Qingqing, Wang, Yan, Yang, Yi, Chen, Chung-Hsuan, Sahin, Aysegul A., Yu, Dihua, Hortobagyi, Gabriel N., Hung, Mien-Chie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-CTLA4 B7-H1 Antigen - chemistry B7-H1 Antigen - metabolism Cell Line, Tumor COP9 Signalosome Complex CSN5 curcumin Curcumin - pharmacology deubiquitination Female Humans Intracellular Signaling Peptides and Proteins - metabolism Mice Neoplasm Transplantation Neoplasms - metabolism NF-kappa B - metabolism PD-L1 Peptide Hydrolases - metabolism Protein Stability TNF-α Tumor Necrosis Factor-alpha - metabolism Ubiquitination
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