In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease

Copper is a required metal nutrient for life, but global or local alterations in its homeostasis are linked to diseases spanning genetic and metabolic disorders to cancer and neurodegeneration. Technologies that enable longitudinal in vivo monitoring of dynamic copper pools can help meet the need to...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-12, Vol.113 (50), p.14219-14224
Hauptverfasser:	Heffern, Marie C., Park, Hyo Min, Au-Yeung, Ho Yu, Van de Bittner, Genevieve C., Ackerman, Cheri M., Stahl, Andreas, Chang, Christopher J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Bioluminescence Copper Copper - deficiency Diet, High-Fat - adverse effects Firefly Luciferin Homeostasis Liver Liver diseases Luciferin Luminescent Agents Luminescent Measurements - methods Male Medical imaging Metabolic disorders Metallochaperones - metabolism Mice Mice, Transgenic Molecular Imaging - methods Non-alcoholic Fatty Liver Disease - diagnostic imaging Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - metabolism Physical Sciences Vitamin deficiency
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