The Organic Arsenic Derivative GMZ27 Induces PML―RARα-Independent Apoptosis in Myeloid Leukemia Cells

Arsenic trioxide (ATO) is an inorganic arsenic derivative that is very effective against acute promyelocytic leukemia. However, organic arsenic derivatives (OAD) have a more favorable toxicity profile than ATO. We herein characterized dipropil-S-glycerol arsenic (GMZ27), a novel OAD. GMZ27 had poten...

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Veröffentlicht in:	Anticancer research 2012-07, Vol.32 (7), p.2871-2880
Hauptverfasser:	CHENG, Xiaodong, QUINTAS-CARDAMA, Alfonso, GOLEMOVIC, Mirna, ZINGARO, Ralph, GAO, Ming-Zhang, FREIREICH, Emil J, ANDREEFF, Michael, KANTARJIAN, Hagop M, VERSTOVSEK, Srdan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - physiology Arsenic Trioxide Arsenicals - pharmacology Biological and medical sciences Caspase 9 - metabolism Cell Cycle - drug effects Cell Growth Processes - drug effects Cell Line, Tumor Chromosome aberrations Dose-Response Relationship, Drug Enzyme Activation - drug effects Female HL-60 Cells Humans Leukemia, Myelomonocytic, Acute - drug therapy Leukemia, Myelomonocytic, Acute - metabolism Leukemia, Myelomonocytic, Acute - pathology Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - metabolism Leukemia, Promyelocytic, Acute - pathology Medical genetics Medical sciences Mice Oncogene Proteins, Fusion - biosynthesis Oxides - pharmacology Oxygen - metabolism Tumors
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