Autophagy activation protects shock wave induced renal tubular epithelial cell apoptosis may through modulation of Akt/ GSK-3β pathway

Extracorporeal shock wave lithotripsy (ESWL) is well documented to exert destructive effect to renal cells and its mechanism is not clear. Autophagy is one of cell basic response for stressful conditions and it is important to determine cell's fate. The aim of this study is to elucidate the rol...

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Veröffentlicht in:	International journal of biological sciences 2016-01, Vol.12 (12), p.1461-1471
Hauptverfasser:	Long, Qingzhi, Li, Xiang, He, Hui, He, Dalin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Apoptosis - physiology Autophagy - genetics Autophagy - physiology Beclin-1 - genetics Beclin-1 - metabolism Cell Line Cell Survival - genetics Cell Survival - physiology Epithelial Cells - cytology Epithelial Cells - metabolism Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism High-Energy Shock Waves - adverse effects Kidney Tubules - cytology Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rats Research Paper Signal Transduction - genetics Signal Transduction - physiology
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