Potent Inhibition of Human Cytomegalovirus by Modulation of Cellular SNARE Syntaxin 5

Formation of the cytoplasmic viral assembly compartment (cVAC) is an important step for efficient human cytomegalovirus (HCMV) assembly. To do this, the virus must alter and repurpose the normal cellular balance of membrane and protein flux, a process that is not well understood. Although a recent s...

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Veröffentlicht in:	Journal of virology 2017-01, Vol.91 (1)
Hauptverfasser:	Cruz, Linda, Streck, Nicholas T, Ferguson, Kevin, Desai, Trisha, Desai, Dhimant H, Amin, Shantu G, Buchkovich, Nicholas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Membrane - drug effects Cell Membrane - metabolism Cell Membrane - ultrastructure Cell Membrane - virology Cytomegalovirus - drug effects Cytomegalovirus - metabolism Cytomegalovirus - ultrastructure Cytoplasm - drug effects Cytoplasm - metabolism Cytoplasm - ultrastructure Cytoplasm - virology Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - ultrastructure Epithelial Cells - virology Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - ultrastructure Fibroblasts - virology Gene Expression Regulation Genes, Reporter Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Herpesviridae Host-Pathogen Interactions Human cytomegalovirus Humans Luminescent Proteins - genetics Luminescent Proteins - metabolism Mice Protein Transport - drug effects Qa-SNARE Proteins - genetics Qa-SNARE Proteins - metabolism Quinazolines - pharmacology Red Fluorescent Protein Signal Transduction Structure and Assembly Virion - drug effects Virion - metabolism Virion - ultrastructure Virus Assembly - drug effects Virus Assembly - genetics
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