CLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In Vivo

Human infections with influenza viruses exhibit mild to severe clinical outcomes as a result of complex virus-host interactions. Induction of inflammatory mediators via pattern recognition receptors may dictate subsequent host responses for pathogen clearance and tissue damage. We identified that hu...

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Veröffentlicht in:	Journal of virology 2017-01, Vol.91 (1)
Hauptverfasser:	Teng, Ooiean, Chen, Szu-Ting, Hsu, Tsui-Ling, Sia, Sin Fun, Cole, Suzanne, Valkenburg, Sophie A, Hsu, Tzu-Yun, Zheng, Jian Teddy, Tu, Wenwei, Bruzzone, Roberto, Peiris, Joseph Sriyal Malik, Hsieh, Shie-Liang, Yen, Hui-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - pharmacology Chemokine CXCL10 - genetics Chemokine CXCL10 - immunology Gene Expression Regulation Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - immunology Host-Pathogen Interactions Humans Influenza A Virus, H1N1 Subtype - growth & development Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H1N1 Subtype - pathogenicity Influenza A Virus, H5N1 Subtype - growth & development Influenza A Virus, H5N1 Subtype - immunology Influenza A Virus, H5N1 Subtype - pathogenicity Interferon-alpha - genetics Interferon-alpha - immunology Lectins, C-Type - antagonists & inhibitors Lectins, C-Type - genetics Lectins, C-Type - immunology Lentivirus - genetics Lentivirus - immunology Lung - drug effects Lung - immunology Lung - virology Macrophages - drug effects Macrophages - immunology Macrophages - virology Macrophages, Alveolar - drug effects Macrophages, Alveolar - immunology Macrophages, Alveolar - virology Mice Mice, Inbred C57BL Mice, Knockout Orthomyxoviridae Orthomyxoviridae Infections - genetics Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - mortality Orthomyxoviridae Infections - virology Pathogenesis and Immunity Primary Cell Culture Protein Binding Protein Isoforms - genetics Protein Isoforms - immunology Receptors, Cell Surface - antagonists & inhibitors Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Survival Analysis Toll-Like Receptor 3 - genetics Toll-Like Receptor 3 - immunology Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology
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