Interferon Regulatory Factor 1 and Type I Interferon Cooperate To Control Acute Gammaherpesvirus Infection

Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection in >95% of adults worldwide and are associated with a variety of malignancies. Coevolution of gammaherpesviruses with their hosts has resulted in an intricate relationship between the virus and the host immune system, a...

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Veröffentlicht in:	Journal of virology 2017-01, Vol.91 (1)
Hauptverfasser:	Mboko, Wadzanai P, Rekow, Michaela M, Ledwith, Mitchell P, Lange, Philip T, Schmitz, Kaitlin E, Anderson, Sean, Tarakanova, Vera L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation, Myelomonocytic - genetics Antigens, Differentiation, Myelomonocytic - immunology Antigens, Nuclear - genetics Antigens, Nuclear - immunology Gammaherpesvirinae Gammaherpesvirinae - growth & development Gammaherpesvirinae - pathogenicity Gene Expression Regulation Herpesviridae Infections - genetics Herpesviridae Infections - immunology Herpesviridae Infections - mortality Herpesviridae Infections - virology Host-Pathogen Interactions Humans Interferon Regulatory Factor-1 - genetics Interferon Regulatory Factor-1 - immunology Interferon Regulatory Factor-3 - genetics Interferon Regulatory Factor-3 - immunology Interferon Regulatory Factor-7 - genetics Interferon Regulatory Factor-7 - immunology Interferon-alpha - genetics Interferon-alpha - immunology Interferon-beta - genetics Interferon-beta - immunology Interferon-gamma - genetics Interferon-gamma - immunology Interferon-Induced Helicase, IFIH1 - genetics Interferon-Induced Helicase, IFIH1 - immunology Lung - immunology Lung - virology Macrophages - immunology Macrophages - virology Mice Mice, Inbred C57BL Mice, Knockout Pathogenesis and Immunity Primary Cell Culture Proteins - genetics Proteins - immunology Receptor, Interferon alpha-beta - genetics Receptor, Interferon alpha-beta - immunology Signal Transduction Spleen - immunology Spleen - virology Survival Analysis
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