Decreased Neointimal Formation in Nox2-Deficient Mice Reveals a Direct Role for NADPH Oxidase in the Response to Arterial Injury

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are produced, in part, from NADPH oxidase in response to host invasion and tissue injury. Defects in NADPH oxidase impair host defense; however, the role of ROS and RNS in the response to tissue injury is not known. We addressed this...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-08, Vol.101 (35), p.13014-13019
Hauptverfasser:	Chen, Zhiping, Keaney, John F., Schulz, Eberhard, Levison, Bruce, Shan, Lian, Sakuma, Masashi, Zhang, Xiaobin, Shi, Can, Hazen, Stanley L., Simon, Daniel I., Braunwald, Eugene
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Blood vessels Cell Division - physiology Cell Movement - physiology Cytochromes b - deficiency Cytochromes b - genetics Cytochromes b - physiology Femoral artery Femoral Artery - injuries Femoral Artery - pathology Femoral Artery - physiology Immunohistochemistry Injuries Leukocytes Leukocytes - physiology Lipids Membrane Glycoproteins Mice NADPH Oxidase 2 NADPH Oxidases - physiology Oxidases Oxidation Physical trauma Reactive Nitrogen Species - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Superoxides Superoxides - metabolism Tissues Vascular system injuries Wound Healing - physiology
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