CDK Substrate Phosphorylation and Ordering the Cell Cycle

S phase and mitotic onset are brought about by the action of multiple different cyclin-CDK complexes. However, it has been suggested that changes in the total level of CDK kinase activity, rather than substrate specificity, drive the temporal ordering of S phase and mitosis. Here, we present a phosp...

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Veröffentlicht in:	Cell 2016-12, Vol.167 (7), p.1750-1761.e16
Hauptverfasser:	Swaffer, Matthew P., Jones, Andrew W., Flynn, Helen R., Snijders, Ambrosius P., Nurse, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	CDK Cell Cycle cyclin-dependent kinase Cyclin-Dependent Kinases - metabolism Cyclins - metabolism kinase Mitosis phosphoproteomics Phosphorylation S phase Schizosaccharomyces - cytology Schizosaccharomyces - metabolism Schizosaccharomyces pombe Proteins - metabolism
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