X-ray structure of the human α4β2 nicotinic receptor

Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate fast chemical neurotransmission; here, the first X-ray crystal structure of a nicotinic receptor is reported, revealing how nicotine stabilizes the receptor in a non-conducting, desensitized conformation. Structure of a nic...

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Veröffentlicht in:	Nature (London) 2016-10, Vol.538 (7625), p.411-415
Hauptverfasser:	Morales-Perez, Claudio L., Noviello, Colleen M., Hibbs, Ryan E.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/2586 631/378/548/1964 631/45/269/1149 631/535/1266 631/57/2271 82/80 82/83 9/74 Binding Sites Bridged Bicyclo Compounds, Heterocyclic - chemistry Bridged Bicyclo Compounds, Heterocyclic - metabolism Crystallography, X-Ray Humanities and Social Sciences Humans Ion Transport letter Ligands Models, Molecular multidisciplinary Neurotransmitter Agents - chemistry Neurotransmitter Agents - metabolism Nicotinic Agonists - chemistry Nicotinic Agonists - metabolism Protein Structure, Quaternary Pyridines - chemistry Pyridines - metabolism Receptors, Nicotinic - chemistry Receptors, Nicotinic - metabolism Science
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