FOXD1-ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells

Glioma stem-like cells (GSC) with tumor-initiating activity orchestrate the cellular hierarchy in glioblastoma and engender therapeutic resistance. Recent work has divided GSC into two subtypes with a mesenchymal (MES) GSC population as the more malignant subtype. In this study, we identify the FOXD...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-12, Vol.76 (24), p.7219-7230
Hauptverfasser:	Cheng, Peng, Wang, Jia, Waghmare, Indrayani, Sartini, Stefania, Coviello, Vito, Zhang, Zhuo, Kim, Sung-Hak, Mohyeldin, Ahmed, Pavlyukov, Marat S, Minata, Mutsuko, Valentim, Claudia L L, Chhipa, Rishi Raj, Bhat, Krishna P L, Dasgupta, Biplab, La Motta, Concettina, Kango-Singh, Madhuri, Nakano, Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Oxidoreductases - metabolism Animals Antineoplastic Agents - pharmacology Blotting, Western Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Proliferation Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Drosophila Fluorescent Antibody Technique Forkhead Transcription Factors - metabolism Glioma - metabolism Glioma - pathology Humans Immunohistochemistry Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - pathology Mice Mice, Nude Microscopy, Confocal Neoplastic Stem Cells - pathology Signal Transduction - physiology Xenograft Model Antitumor Assays
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