Neutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection

HIV-1 infection occurs primarily through mucosal transmission. Application of biologically relevant mucosal models can advance understanding of the functional properties of antibodies that mediate HIV protection, thereby guiding antibody-based vaccine development. Here, we employed a human ex vivo v...

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Veröffentlicht in:	EBioMedicine 2016-12, Vol.14, p.97-111
Hauptverfasser:	Astronomo, Rena D., Santra, Sampa, Ballweber-Fleming, Lamar, Westerberg, Katharine G., Mach, Linh, Hensley-McBain, Tiffany, Sutherland, Laura, Mildenberg, Benjamin, Morton, Georgeanna, Yates, Nicole L., Mize, Gregory J., Pollara, Justin, Hladik, Florian, Ochsenbauer, Christina, Denny, Thomas N., Warrier, Ranjit, Rerks-Ngarm, Supachai, Pitisuttithum, Punnee, Nitayapan, Sorachai, Kaewkungwal, Jaranit, Ferrari, Guido, Shaw, George M., Xia, Shi-Mao, Liao, Hua-Xin, Montefiori, David C., Tomaras, Georgia D., Haynes, Barton F., McElrath, M. Juliana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Neutralizing - immunology Biomarkers Disease Models, Animal Female HIV Antibodies - immunology HIV Infections - immunology HIV Infections - prevention & control HIV Infections - virology HIV-1 HIV-1 - genetics HIV-1 - immunology Humans IgA IgG Immunity, Mucosal Immunoglobulin A - immunology Immunoglobulin G - immunology Immunophenotyping Leukocytes - immunology Leukocytes - metabolism Macaca mulatta Mucosal immunology Mucous Membrane - immunology Mucous Membrane - virology Neutralization Tests Neutralizing antibodies Non-human primate rectal challenge model Research Paper Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian Acquired Immunodeficiency Syndrome - virology Simian Immunodeficiency Virus - immunology Vagina - immunology Vagina - virology Vaginal explants
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