The Identification of a Novel Mutant Allele of topoisomerase II in Caenorhabditis elegans Reveals a Unique Role in Chromosome Segregation During Spermatogenesis

Topoisomerase II alleviates DNA entanglements that are generated during mitotic DNA replication, transcription, and sister chromatid separation. In contrast to mitosis, meiosis has two rounds of chromosome segregation following one round of DNA replication. In meiosis II, sister chromatids segregate...

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Veröffentlicht in:	Genetics (Austin) 2016-12, Vol.204 (4), p.1407-1422
Hauptverfasser:	Jaramillo-Lambert, Aimee, Fabritius, Amy S, Hansen, Tyler J, Smith, Harold E, Golden, Andy
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Chromosome Segregation Chromosomes DNA Topoisomerases, Type II - genetics DNA Topoisomerases, Type II - metabolism Female Genes Investigations Male Meiosis Mutation Nematodes Spermatogenesis Yeast
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