Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone
The objective of this study was to investigate the therapeutic effects of the application of fascial flap-wrapped allogeneic bone for repair of large segmental tibial defects in rabbits and provide a theoretical basis for treatment of large segmental defects in weight-bearing bones. Forty-eight heal...
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| Veröffentlicht in: | Journal of orthopaedic surgery and research 2016-12, Vol.11 (1), p.162-162, Article 162 |
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| creator | Dou, Honglei Wang, Guowei Xing, Na Zhang, Lina |
| description | The objective of this study was to investigate the therapeutic effects of the application of fascial flap-wrapped allogeneic bone for repair of large segmental tibial defects in rabbits and provide a theoretical basis for treatment of large segmental defects in weight-bearing bones.
Forty-eight healthy adult New Zealand White (NZW) rabbits were randomized into two groups to establish 15-mm bone defects in the proximal tibia. Bone defects in test and control groups were repaired using allogeneic bone with and without a vascularized fascial flap from the rabbit proximal tibia, respectively. The differences in repair of bone defects between the two groups were assessed with postoperative X-ray examination, new bone quantity assessment, serum bone Gla protein (BGP) level, and biomechanical testing.
The therapeutic effect in the test group was superior to that in the control group.
Fascial flap-wrapped allogeneic bone is superior to allogeneic bone alone, and is ideal for the treatment of large segmental bone defects. |
| doi_str_mv | 10.1186/s13018-016-0492-9 |
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Forty-eight healthy adult New Zealand White (NZW) rabbits were randomized into two groups to establish 15-mm bone defects in the proximal tibia. Bone defects in test and control groups were repaired using allogeneic bone with and without a vascularized fascial flap from the rabbit proximal tibia, respectively. The differences in repair of bone defects between the two groups were assessed with postoperative X-ray examination, new bone quantity assessment, serum bone Gla protein (BGP) level, and biomechanical testing.
The therapeutic effect in the test group was superior to that in the control group.
Fascial flap-wrapped allogeneic bone is superior to allogeneic bone alone, and is ideal for the treatment of large segmental bone defects.</description><identifier>ISSN: 1749-799X</identifier><identifier>EISSN: 1749-799X</identifier><identifier>DOI: 10.1186/s13018-016-0492-9</identifier><identifier>PMID: 27978849</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Animals ; Bone diseases ; Bone transplantation ; Care and treatment ; Fascia ; Fractures, Bone - diagnostic imaging ; Fractures, Bone - surgery ; Orthopedics ; Patient outcomes ; Physiological aspects ; Rabbits ; Random Allocation ; Surgical Flaps ; Tibia - diagnostic imaging ; Tibia - injuries ; Tibia - surgery ; Transplantation, Homologous - methods</subject><ispartof>Journal of orthopaedic surgery and research, 2016-12, Vol.11 (1), p.162-162, Article 162</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-86a8626d879fea01ebdae93805d7564b97d17507bb497e43ee3a4ee6443286463</citedby><cites>FETCH-LOGICAL-c494t-86a8626d879fea01ebdae93805d7564b97d17507bb497e43ee3a4ee6443286463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159971/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159971/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27978849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dou, Honglei</creatorcontrib><creatorcontrib>Wang, Guowei</creatorcontrib><creatorcontrib>Xing, Na</creatorcontrib><creatorcontrib>Zhang, Lina</creatorcontrib><title>Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone</title><title>Journal of orthopaedic surgery and research</title><addtitle>J Orthop Surg Res</addtitle><description>The objective of this study was to investigate the therapeutic effects of the application of fascial flap-wrapped allogeneic bone for repair of large segmental tibial defects in rabbits and provide a theoretical basis for treatment of large segmental defects in weight-bearing bones.
Forty-eight healthy adult New Zealand White (NZW) rabbits were randomized into two groups to establish 15-mm bone defects in the proximal tibia. Bone defects in test and control groups were repaired using allogeneic bone with and without a vascularized fascial flap from the rabbit proximal tibia, respectively. The differences in repair of bone defects between the two groups were assessed with postoperative X-ray examination, new bone quantity assessment, serum bone Gla protein (BGP) level, and biomechanical testing.
The therapeutic effect in the test group was superior to that in the control group.
Fascial flap-wrapped allogeneic bone is superior to allogeneic bone alone, and is ideal for the treatment of large segmental bone defects.</description><subject>Animals</subject><subject>Bone diseases</subject><subject>Bone transplantation</subject><subject>Care and treatment</subject><subject>Fascia</subject><subject>Fractures, Bone - diagnostic imaging</subject><subject>Fractures, Bone - surgery</subject><subject>Orthopedics</subject><subject>Patient outcomes</subject><subject>Physiological aspects</subject><subject>Rabbits</subject><subject>Random Allocation</subject><subject>Surgical Flaps</subject><subject>Tibia - diagnostic imaging</subject><subject>Tibia - injuries</subject><subject>Tibia - surgery</subject><subject>Transplantation, Homologous - methods</subject><issn>1749-799X</issn><issn>1749-799X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkk1rFjEUhYNYbK3-ADcy4MbN1NyZfG6EUvyCgqVUcBcymTvTlMxkTOZt6b9vXt9aW5EsEnKfc5KbHELeAD0CUOJDhpaCqimImjLd1PoZOQDJdC21_vn80XqfvMz5ilJOuWIvyH4jtVSK6QNydo6L9amKQxVsGrHKOE44rzZUXZyx6nFAt-bqxq-X1WCz86UyBLvUN8kuC_aVDSGOOKN3vxWvyN5gQ8bX9_Mh-fH508XJ1_r0-5dvJ8entWOarbUSVolG9ErqAS0F7HqLulWU95IL1mnZg-RUdh3TElmL2FqGKBhrGyWYaA_Jx53vsukm7F25c7LBLMlPNt2aaL15Wpn9pRnjteHAtZZQDN7fG6T4a4N5NZPPDkOwM8ZNNqA4NBqUVAV99w96FTdpLu1tKc4aBg39S402oPHzEMu5bmtqjplkVAAXbaGO_kOV0ePkXXnAwZf9JwLYCVyKOSccHnoEarYxMLsYmBIDs42B0UXz9vHjPCj-_Ht7B6QcrH4</recordid><startdate>20161215</startdate><enddate>20161215</enddate><creator>Dou, Honglei</creator><creator>Wang, Guowei</creator><creator>Xing, Na</creator><creator>Zhang, Lina</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161215</creationdate><title>Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone</title><author>Dou, Honglei ; Wang, Guowei ; Xing, Na ; Zhang, Lina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-86a8626d879fea01ebdae93805d7564b97d17507bb497e43ee3a4ee6443286463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Bone diseases</topic><topic>Bone transplantation</topic><topic>Care and treatment</topic><topic>Fascia</topic><topic>Fractures, Bone - diagnostic imaging</topic><topic>Fractures, Bone - surgery</topic><topic>Orthopedics</topic><topic>Patient outcomes</topic><topic>Physiological aspects</topic><topic>Rabbits</topic><topic>Random Allocation</topic><topic>Surgical Flaps</topic><topic>Tibia - diagnostic imaging</topic><topic>Tibia - injuries</topic><topic>Tibia - surgery</topic><topic>Transplantation, Homologous - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dou, Honglei</creatorcontrib><creatorcontrib>Wang, Guowei</creatorcontrib><creatorcontrib>Xing, Na</creatorcontrib><creatorcontrib>Zhang, Lina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of orthopaedic surgery and research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dou, Honglei</au><au>Wang, Guowei</au><au>Xing, Na</au><au>Zhang, Lina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone</atitle><jtitle>Journal of orthopaedic surgery and research</jtitle><addtitle>J Orthop Surg Res</addtitle><date>2016-12-15</date><risdate>2016</risdate><volume>11</volume><issue>1</issue><spage>162</spage><epage>162</epage><pages>162-162</pages><artnum>162</artnum><issn>1749-799X</issn><eissn>1749-799X</eissn><abstract>The objective of this study was to investigate the therapeutic effects of the application of fascial flap-wrapped allogeneic bone for repair of large segmental tibial defects in rabbits and provide a theoretical basis for treatment of large segmental defects in weight-bearing bones.
Forty-eight healthy adult New Zealand White (NZW) rabbits were randomized into two groups to establish 15-mm bone defects in the proximal tibia. Bone defects in test and control groups were repaired using allogeneic bone with and without a vascularized fascial flap from the rabbit proximal tibia, respectively. The differences in repair of bone defects between the two groups were assessed with postoperative X-ray examination, new bone quantity assessment, serum bone Gla protein (BGP) level, and biomechanical testing.
The therapeutic effect in the test group was superior to that in the control group.
Fascial flap-wrapped allogeneic bone is superior to allogeneic bone alone, and is ideal for the treatment of large segmental bone defects.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27978849</pmid><doi>10.1186/s13018-016-0492-9</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Bone diseases Bone transplantation Care and treatment Fascia Fractures, Bone - diagnostic imaging Fractures, Bone - surgery Orthopedics Patient outcomes Physiological aspects Rabbits Random Allocation Surgical Flaps Tibia - diagnostic imaging Tibia - injuries Tibia - surgery Transplantation, Homologous - methods |
| title | Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone |
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