The lncRNA HOTAIR impacts on mesenchymal stem cells via triple helix formation

There is a growing perception that long non-coding RNAs (lncRNAs) modulate cellular function. In this study, we analyzed the role of the lncRNA HOTAIR in mesenchymal stem cells (MSCs) with particular focus on senescence-associated changes in gene expression and DNA-methylation (DNAm). HOTAIR binding...

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Veröffentlicht in:	Nucleic acids research 2016-12, Vol.44 (22), p.10631-10643
Hauptverfasser:	Kalwa, Marie, Hänzelmann, Sonja, Otto, Sabrina, Kuo, Chao-Chung, Franzen, Julia, Joussen, Sylvia, Fernandez-Rebollo, Eduardo, Rath, Björn, Koch, Carmen, Hofmann, Andrea, Lee, Shih-Han, Teschendorff, Andrew E, Denecke, Bernd, Lin, Qiong, Widschwendter, Martin, Weinhold, Elmar, Costa, Ivan G, Wagner, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Cell Differentiation Cell Proliferation Cells, Cultured Cellular Senescence DNA Methylation Epigenesis, Genetic Gene Expression Gene regulation, Chromatin and Epigenetics Humans Mesenchymal Stromal Cells - physiology Nucleic Acid Conformation Protein Binding RNA, Long Noncoding - chemistry RNA, Long Noncoding - physiology
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