Hyperphagia in male melanocortin 4 receptor deficient mice promotes growth independently of growth hormone

Key points Loss of function of the melanocortin 4 receptor (MC4R) results in hyperphagia, obesity and increased growth. Despite knowing that MC4Rs control food intake, we are yet to understand why defects in the function of the MC4R receptor contribute to rapid linear growth. We show that hyperphagi...

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Veröffentlicht in:	The Journal of physiology 2016-12, Vol.594 (24), p.7309-7326
Hauptverfasser:	Tan, H. Y., Steyn, F. J., Huang, L., Cowley, M., Veldhuis, J. D., Chen, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue and Obesity Animals Brain - metabolism Defects Endocrinology and Metabolism energy homeostasis Green Fluorescent Proteins - genetics growth Growth Hormone - genetics Growth Hormone - metabolism Growth Hormone-Releasing Hormone - genetics Growth hormones hyperinsulinemia hyperphagia Hyperphagia - metabolism Insulin Insulin - blood Insulin-Like Growth Factor I - metabolism Insulin-like growth factors Leptin - blood Male melanocortin 4 receptor Mice, Inbred C57BL Mice, Transgenic Muscle, Skeletal - metabolism Neurons - metabolism Obesity Obesity - metabolism Physiology puberty Receptor, Melanocortin, Type 4 - deficiency Receptor, Melanocortin, Type 4 - genetics Receptor, Melanocortin, Type 4 - metabolism Renal and Endocrine Research Paper Rodents
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