Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport

Abnormal dopaminergic transmission has been implicated as a risk determinant of HIV-1-associated neurocognitive disorders. HIV-1 Tat protein increases synaptic dopamine (DA) levels by directly inhibiting DA transporter (DAT) activity, ultimately leading to dopaminergic neuron damage. Through integra...

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Veröffentlicht in:	Scientific reports 2016-12, Vol.6 (1), p.39048-39048, Article 39048
Hauptverfasser:	Quizon, Pamela M., Sun, Wei-Lun, Yuan, Yaxia, Midde, Narasimha M., Zhan, Chang-Guo, Zhu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/116 692/617/375 Amino Acid Substitution Animals Binding Sites Cognition Computational neuroscience Dopamine Dopamine Plasma Membrane Transport Proteins - chemistry Dopamine Plasma Membrane Transport Proteins - genetics Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine receptors Dopamine transporter Gene Expression Regulation, Viral Histidine Histidine - genetics Histidine - metabolism HIV-1 - metabolism Humanities and Social Sciences Humans Kinetics Models, Molecular multidisciplinary PC12 Cells Protein Binding Protein Conformation Protein kinase C Protein transport Rats Science tat Gene Products, Human Immunodeficiency Virus - metabolism Tat protein
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