Long-term prognostic impact of circulating tumour cells in gastric cancer patients
AIM To analyse the long-term prognostic impact of circulating tumour cells(CTCs) in gastric cancer patients who underwent surgery. METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerasespecifi...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2016-12, Vol.22 (46), p.10232-10241 |
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| creator | Ito, Hiroaki Sato, Jun Tsujino, Yukio Yamaguchi, Noriko Kimura, Satoshi Gohda, Keigo Murakami, Katsuhiro Onimaru, Manabu Ohmori, Tohru Ishikawa, Fumihiro Inoue, Haruhiro |
| description | AIM To analyse the long-term prognostic impact of circulating tumour cells(CTCs) in gastric cancer patients who underwent surgery. METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerasespecific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein gene, was used to label CTCs. Correlations between the number of CTCs and clinical end points were evaluated. RESULTS The median follow-up period of the surviving patients with gastric cancer was 60 mo. The CTC number tended to increase concomitantly with disease progression. The overall survival of patients with more than five CTCs in 7.5-m L of peripheral blood was lower than that of patients with five or less CTCs, although the difference was not significant(P = 0.183). A significant difference in relapse-free survival was found between patients with more than five and those with five or less CTCs(P = 0.034).CONCLUSION A lower number of CTCs was correlated with higher relapse-free survival rates in patients. Detection of CTCs using OBP-401 may be useful for predicting prognosis in gastric cancer. |
| doi_str_mv | 10.3748/wjg.v22.i46.10232 |
| format | Article |
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METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerasespecific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein gene, was used to label CTCs. Correlations between the number of CTCs and clinical end points were evaluated. RESULTS The median follow-up period of the surviving patients with gastric cancer was 60 mo. The CTC number tended to increase concomitantly with disease progression. The overall survival of patients with more than five CTCs in 7.5-m L of peripheral blood was lower than that of patients with five or less CTCs, although the difference was not significant(P = 0.183). A significant difference in relapse-free survival was found between patients with more than five and those with five or less CTCs(P = 0.034).CONCLUSION A lower number of CTCs was correlated with higher relapse-free survival rates in patients. Detection of CTCs using OBP-401 may be useful for predicting prognosis in gastric cancer.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v22.i46.10232</identifier><identifier>PMID: 28028372</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Adenocarcinoma - blood ; Adenocarcinoma - mortality ; Adenocarcinoma - therapy ; Adult ; Aged ; Case-Control Studies ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Female ; Gastrectomy ; Humans ; Male ; Middle Aged ; Neoplastic Cells, Circulating ; Prognosis ; Prospective Study ; Stomach Neoplasms - blood ; Stomach Neoplasms - mortality ; Stomach Neoplasms - therapy</subject><ispartof>World journal of gastroenterology : WJG, 2016-12, Vol.22 (46), p.10232-10241</ispartof><rights>The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. 2016</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-3f45b289f5415bb41b2269a636568ec25544d3e3e8e6668fad9b9424c2f51c113</citedby><cites>FETCH-LOGICAL-c443t-3f45b289f5415bb41b2269a636568ec25544d3e3e8e6668fad9b9424c2f51c113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155183/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155183/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28028372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ito, Hiroaki</creatorcontrib><creatorcontrib>Sato, Jun</creatorcontrib><creatorcontrib>Tsujino, Yukio</creatorcontrib><creatorcontrib>Yamaguchi, Noriko</creatorcontrib><creatorcontrib>Kimura, Satoshi</creatorcontrib><creatorcontrib>Gohda, Keigo</creatorcontrib><creatorcontrib>Murakami, Katsuhiro</creatorcontrib><creatorcontrib>Onimaru, Manabu</creatorcontrib><creatorcontrib>Ohmori, Tohru</creatorcontrib><creatorcontrib>Ishikawa, Fumihiro</creatorcontrib><creatorcontrib>Inoue, Haruhiro</creatorcontrib><title>Long-term prognostic impact of circulating tumour cells in gastric cancer patients</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM To analyse the long-term prognostic impact of circulating tumour cells(CTCs) in gastric cancer patients who underwent surgery. METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerasespecific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein gene, was used to label CTCs. Correlations between the number of CTCs and clinical end points were evaluated. RESULTS The median follow-up period of the surviving patients with gastric cancer was 60 mo. The CTC number tended to increase concomitantly with disease progression. The overall survival of patients with more than five CTCs in 7.5-m L of peripheral blood was lower than that of patients with five or less CTCs, although the difference was not significant(P = 0.183). A significant difference in relapse-free survival was found between patients with more than five and those with five or less CTCs(P = 0.034).CONCLUSION A lower number of CTCs was correlated with higher relapse-free survival rates in patients. Detection of CTCs using OBP-401 may be useful for predicting prognosis in gastric cancer.</description><subject>Adenocarcinoma - blood</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - therapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Chemotherapy, Adjuvant</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplastic Cells, Circulating</subject><subject>Prognosis</subject><subject>Prospective Study</subject><subject>Stomach Neoplasms - blood</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - therapy</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU9v1DAQxS1ERbeFD8AF-cgliz3-E_uChCoKSCshVXC2HK-Tukri1HaK-u3rbZcV-DKW_Js3nvcQek_JlrVcffpzN2wfALaByy0lwOAV2gBQ3YDi5DXaUELaRjNoz9FFznekIkzAG3QOioBiLWzQzS7OQ1N8mvCS4jDHXILDYVqsKzj22IXk1tGWMA-4rFNcE3Z-HDMOMx5sLqnSzs7OJ7xUys8lv0VnvR2zf3esl-j39ddfV9-b3c9vP66-7BrHOSsN67noQOlecCq6jtMOQGormRRSeQdCcL5nnnnlpZSqt3vdaQ7cQS-oo5Rdos8vusvaTX7v6uxkR7OkMNn0aKIN5v-XOdyaIT4YQYWgilWBj0eBFO9Xn4uZQj5sZ2cf12yoEtVmCc8ofUFdijkn35_GUGIOWZiahalZmJqFec6i9nz493-njr_mV4AdRW9rCPfV4hOjiTocLQhXXAsuoLpxuLXsCVnLluA</recordid><startdate>20161214</startdate><enddate>20161214</enddate><creator>Ito, Hiroaki</creator><creator>Sato, Jun</creator><creator>Tsujino, Yukio</creator><creator>Yamaguchi, Noriko</creator><creator>Kimura, Satoshi</creator><creator>Gohda, Keigo</creator><creator>Murakami, Katsuhiro</creator><creator>Onimaru, Manabu</creator><creator>Ohmori, Tohru</creator><creator>Ishikawa, Fumihiro</creator><creator>Inoue, Haruhiro</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161214</creationdate><title>Long-term prognostic impact of circulating tumour cells in gastric cancer patients</title><author>Ito, Hiroaki ; Sato, Jun ; Tsujino, Yukio ; Yamaguchi, Noriko ; Kimura, Satoshi ; Gohda, Keigo ; Murakami, Katsuhiro ; Onimaru, Manabu ; Ohmori, Tohru ; Ishikawa, Fumihiro ; Inoue, Haruhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-3f45b289f5415bb41b2269a636568ec25544d3e3e8e6668fad9b9424c2f51c113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenocarcinoma - blood</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - therapy</topic><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Chemotherapy, Adjuvant</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplastic Cells, Circulating</topic><topic>Prognosis</topic><topic>Prospective Study</topic><topic>Stomach Neoplasms - blood</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - therapy</topic><toplevel>online_resources</toplevel><creatorcontrib>Ito, Hiroaki</creatorcontrib><creatorcontrib>Sato, Jun</creatorcontrib><creatorcontrib>Tsujino, Yukio</creatorcontrib><creatorcontrib>Yamaguchi, Noriko</creatorcontrib><creatorcontrib>Kimura, Satoshi</creatorcontrib><creatorcontrib>Gohda, Keigo</creatorcontrib><creatorcontrib>Murakami, Katsuhiro</creatorcontrib><creatorcontrib>Onimaru, Manabu</creatorcontrib><creatorcontrib>Ohmori, Tohru</creatorcontrib><creatorcontrib>Ishikawa, Fumihiro</creatorcontrib><creatorcontrib>Inoue, Haruhiro</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Hiroaki</au><au>Sato, Jun</au><au>Tsujino, Yukio</au><au>Yamaguchi, Noriko</au><au>Kimura, Satoshi</au><au>Gohda, Keigo</au><au>Murakami, Katsuhiro</au><au>Onimaru, Manabu</au><au>Ohmori, Tohru</au><au>Ishikawa, Fumihiro</au><au>Inoue, Haruhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term prognostic impact of circulating tumour cells in gastric cancer patients</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2016-12-14</date><risdate>2016</risdate><volume>22</volume><issue>46</issue><spage>10232</spage><epage>10241</epage><pages>10232-10241</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM To analyse the long-term prognostic impact of circulating tumour cells(CTCs) in gastric cancer patients who underwent surgery. METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerasespecific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein gene, was used to label CTCs. Correlations between the number of CTCs and clinical end points were evaluated. RESULTS The median follow-up period of the surviving patients with gastric cancer was 60 mo. The CTC number tended to increase concomitantly with disease progression. The overall survival of patients with more than five CTCs in 7.5-m L of peripheral blood was lower than that of patients with five or less CTCs, although the difference was not significant(P = 0.183). A significant difference in relapse-free survival was found between patients with more than five and those with five or less CTCs(P = 0.034).CONCLUSION A lower number of CTCs was correlated with higher relapse-free survival rates in patients. Detection of CTCs using OBP-401 may be useful for predicting prognosis in gastric cancer.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>28028372</pmid><doi>10.3748/wjg.v22.i46.10232</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2016-12, Vol.22 (46), p.10232-10241 |
| issn | 1007-9327 2219-2840 |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - blood Adenocarcinoma - mortality Adenocarcinoma - therapy Adult Aged Case-Control Studies Chemotherapy, Adjuvant Disease-Free Survival Female Gastrectomy Humans Male Middle Aged Neoplastic Cells, Circulating Prognosis Prospective Study Stomach Neoplasms - blood Stomach Neoplasms - mortality Stomach Neoplasms - therapy |
| title | Long-term prognostic impact of circulating tumour cells in gastric cancer patients |
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