Cortical gray & subcortical white matter associations in Parkinson’s disease
Abstract Cortical atrophy has been documented in both Parkinson’s disease (PD) and healthy aging, but its relationship to changes in subcortical white matter is unknown. This was investigated by obtaining T1- and diffusion-weighted images from 76 PD and 70 controls at baseline, 18-, and 36-months, f...
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| Veröffentlicht in: | Neurobiology of aging 2017-01, Vol.49, p.100-108 |
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| creator | Sterling, N.W., Ph.D., M.S Du, G., M.D. Ph.D Lewis, M.M., Ph.D Swavely, S., M.D Kong, L., Ph.D Styner, M., Ph.D Huang, X., M.D., Ph.D |
| description | Abstract Cortical atrophy has been documented in both Parkinson’s disease (PD) and healthy aging, but its relationship to changes in subcortical white matter is unknown. This was investigated by obtaining T1- and diffusion-weighted images from 76 PD and 70 controls at baseline, 18-, and 36-months, from which cortical volumes and underlying subcortical white matter axial (AD), radial (RD) diffusivities, and fractional anisotropy (FA) were determined. Twelve of 69 cortical subregions had significant group differences, and for these underlying subcortical white matter was explored. At baseline, higher cortical volumes were significantly correlated with lower underlying subcortical white matter AD, RD, and higher FA (Ps ≤0.017) in PD. Longitudinally, higher rates of cortical atrophy in PD were associated with increased rates of change in AD RD, and FA values (Ps ≤ 0.0013) in two subregions explored. The significant gray-white matter associations were not found in controls. Thus, unlike healthy aging, cortical atrophy and subcortical white matter changes may not be independent events in PD. |
| doi_str_mv | 10.1016/j.neurobiolaging.2016.09.015 |
| format | Article |
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This was investigated by obtaining T1- and diffusion-weighted images from 76 PD and 70 controls at baseline, 18-, and 36-months, from which cortical volumes and underlying subcortical white matter axial (AD), radial (RD) diffusivities, and fractional anisotropy (FA) were determined. Twelve of 69 cortical subregions had significant group differences, and for these underlying subcortical white matter was explored. At baseline, higher cortical volumes were significantly correlated with lower underlying subcortical white matter AD, RD, and higher FA (Ps ≤0.017) in PD. Longitudinally, higher rates of cortical atrophy in PD were associated with increased rates of change in AD RD, and FA values (Ps ≤ 0.0013) in two subregions explored. The significant gray-white matter associations were not found in controls. Thus, unlike healthy aging, cortical atrophy and subcortical white matter changes may not be independent events in PD.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2016.09.015</identifier><identifier>PMID: 27776262</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Anisotropy ; Atrophy ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - pathology ; Cortical atrophy ; Diffusion Magnetic Resonance Imaging ; Diffusion Tensor Imaging ; Female ; Gray Matter - diagnostic imaging ; Gray Matter - pathology ; Humans ; Internal Medicine ; Male ; Middle Aged ; Myelin ; Myelin Sheath ; Neuroimaging ; Neurology ; Parkinson Disease - diagnostic imaging ; Parkinson Disease - pathology ; Parkinson's disease ; White matter ; White Matter - diagnostic imaging ; White Matter - pathology</subject><ispartof>Neurobiology of aging, 2017-01, Vol.49, p.100-108</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c620t-c5cbf9f5cd09c6fe3234cb3b2b602769df48229879f964ae6e9692f4a02c03863</citedby><cites>FETCH-LOGICAL-c620t-c5cbf9f5cd09c6fe3234cb3b2b602769df48229879f964ae6e9692f4a02c03863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0197458016302299$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27776262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sterling, N.W., Ph.D., M.S</creatorcontrib><creatorcontrib>Du, G., M.D. Ph.D</creatorcontrib><creatorcontrib>Lewis, M.M., Ph.D</creatorcontrib><creatorcontrib>Swavely, S., M.D</creatorcontrib><creatorcontrib>Kong, L., Ph.D</creatorcontrib><creatorcontrib>Styner, M., Ph.D</creatorcontrib><creatorcontrib>Huang, X., M.D., Ph.D</creatorcontrib><title>Cortical gray & subcortical white matter associations in Parkinson’s disease</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Abstract Cortical atrophy has been documented in both Parkinson’s disease (PD) and healthy aging, but its relationship to changes in subcortical white matter is unknown. This was investigated by obtaining T1- and diffusion-weighted images from 76 PD and 70 controls at baseline, 18-, and 36-months, from which cortical volumes and underlying subcortical white matter axial (AD), radial (RD) diffusivities, and fractional anisotropy (FA) were determined. Twelve of 69 cortical subregions had significant group differences, and for these underlying subcortical white matter was explored. At baseline, higher cortical volumes were significantly correlated with lower underlying subcortical white matter AD, RD, and higher FA (Ps ≤0.017) in PD. Longitudinally, higher rates of cortical atrophy in PD were associated with increased rates of change in AD RD, and FA values (Ps ≤ 0.0013) in two subregions explored. The significant gray-white matter associations were not found in controls. Thus, unlike healthy aging, cortical atrophy and subcortical white matter changes may not be independent events in PD.</description><subject>Aged</subject><subject>Anisotropy</subject><subject>Atrophy</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Cortex - pathology</subject><subject>Cortical atrophy</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Diffusion Tensor Imaging</subject><subject>Female</subject><subject>Gray Matter - diagnostic imaging</subject><subject>Gray Matter - pathology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myelin</subject><subject>Myelin Sheath</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Parkinson Disease - diagnostic imaging</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson's disease</subject><subject>White matter</subject><subject>White Matter - diagnostic imaging</subject><subject>White Matter - pathology</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks9u1DAQxi0EokvhFVAOCHFJsB3_iSVUqVpRQKoACTiPHGey9TZrFzsp2huvwevxJCTatqKcOI008803o_kNIS8YrRhl6vW2Cjil2Po42I0Pm4rP2YqaijL5gKyYlE3JhNEPyYoyo0shG3pEnuS8pZRqodVjcsS11oorviIf1zGN3tmh2CS7L14WeWrdberHhR-x2NlxxFTYnKPzdvQx5MKH4rNNlz7kGH7__JWLzme0GZ-SR70dMj67icfk29nbr-v35fmndx_Wp-elU5yOpZOu7U0vXUeNUz3WvBaurVveKsq1Ml0vGs5No01vlLCo0CjDe2Epd7RuVH1MTg6-V1O7w85hGJMd4Cr5nU17iNbD_UrwF7CJ1yCZFI3Qs8GrG4MUv0-YR9j57HAYbMA4ZWBNLZU2RvJZ-uYgdSnmnLC_G8MoLEhgC_eRwIIEqIEZydz-_O9V75pvGcyCs4MA54Nde0yQncfgsPMJ3Qhd9P876eQfIzf4sJC8xD3mbZxSmKEAg8yBwpflPZbvYKqm87VN_Qebbr3T</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Sterling, N.W., Ph.D., M.S</creator><creator>Du, G., M.D. Ph.D</creator><creator>Lewis, M.M., Ph.D</creator><creator>Swavely, S., M.D</creator><creator>Kong, L., Ph.D</creator><creator>Styner, M., Ph.D</creator><creator>Huang, X., M.D., Ph.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>Cortical gray & subcortical white matter associations in Parkinson’s disease</title><author>Sterling, N.W., Ph.D., M.S ; Du, G., M.D. Ph.D ; Lewis, M.M., Ph.D ; Swavely, S., M.D ; Kong, L., Ph.D ; Styner, M., Ph.D ; Huang, X., M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c620t-c5cbf9f5cd09c6fe3234cb3b2b602769df48229879f964ae6e9692f4a02c03863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Anisotropy</topic><topic>Atrophy</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Cerebral Cortex - pathology</topic><topic>Cortical atrophy</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Diffusion Tensor Imaging</topic><topic>Female</topic><topic>Gray Matter - diagnostic imaging</topic><topic>Gray Matter - pathology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myelin</topic><topic>Myelin Sheath</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Parkinson Disease - diagnostic imaging</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson's disease</topic><topic>White matter</topic><topic>White Matter - diagnostic imaging</topic><topic>White Matter - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sterling, N.W., Ph.D., M.S</creatorcontrib><creatorcontrib>Du, G., M.D. Ph.D</creatorcontrib><creatorcontrib>Lewis, M.M., Ph.D</creatorcontrib><creatorcontrib>Swavely, S., M.D</creatorcontrib><creatorcontrib>Kong, L., Ph.D</creatorcontrib><creatorcontrib>Styner, M., Ph.D</creatorcontrib><creatorcontrib>Huang, X., M.D., Ph.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sterling, N.W., Ph.D., M.S</au><au>Du, G., M.D. Ph.D</au><au>Lewis, M.M., Ph.D</au><au>Swavely, S., M.D</au><au>Kong, L., Ph.D</au><au>Styner, M., Ph.D</au><au>Huang, X., M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortical gray & subcortical white matter associations in Parkinson’s disease</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>49</volume><spage>100</spage><epage>108</epage><pages>100-108</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>Abstract Cortical atrophy has been documented in both Parkinson’s disease (PD) and healthy aging, but its relationship to changes in subcortical white matter is unknown. This was investigated by obtaining T1- and diffusion-weighted images from 76 PD and 70 controls at baseline, 18-, and 36-months, from which cortical volumes and underlying subcortical white matter axial (AD), radial (RD) diffusivities, and fractional anisotropy (FA) were determined. Twelve of 69 cortical subregions had significant group differences, and for these underlying subcortical white matter was explored. At baseline, higher cortical volumes were significantly correlated with lower underlying subcortical white matter AD, RD, and higher FA (Ps ≤0.017) in PD. Longitudinally, higher rates of cortical atrophy in PD were associated with increased rates of change in AD RD, and FA values (Ps ≤ 0.0013) in two subregions explored. The significant gray-white matter associations were not found in controls. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Anisotropy Atrophy Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology Cortical atrophy Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging Female Gray Matter - diagnostic imaging Gray Matter - pathology Humans Internal Medicine Male Middle Aged Myelin Myelin Sheath Neuroimaging Neurology Parkinson Disease - diagnostic imaging Parkinson Disease - pathology Parkinson's disease White matter White Matter - diagnostic imaging White Matter - pathology |
| title | Cortical gray & subcortical white matter associations in Parkinson’s disease |
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