A phase 2 trial exploring the clinical and correlative effects of combining doxycycline with bone-targeted therapy in patients with metastatic breast cancer

Abstract Background Bone-targeting agents (BTAs), such as bisphosphonates and denosumab, have demonstrated no discernable effects on tumour response or disease free/overall survival in patients with bone metastases from breast cancer. Doxycycline is both osteotropic and has anti-cancer effects. When...

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Veröffentlicht in:	Journal of bone oncology 2016-11, Vol.5 (4), p.173-179
Hauptverfasser:	Addison, C.L, Simos, D, Wang, Z, Pond, G, Smith, S, Robertson, S, Mazzarello, S, Singh, G, Vandermeer, L, Fernandes, R, Iyengar, A, Verma, S, Clemons, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Bisphosphonate Bone metastasis Breast cancer Doxycycline Hematology, Oncology and Palliative Medicine Research Paper
Online-Zugang:	Volltext
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