Flavonol and imidazole derivatives block HPV16 E6 activities and reactivate apoptotic pathways in HPV+ cells

High-risk human papillomaviruses (HR-HPVs) cause nearly all cases of cervical cancer, as well as approximately 30% of head and neck cancers. HPV 16 E6, one of two major viral oncogenes, protects cells from apoptosis by binding to and accelerating the degradation of several proteins important in apop...

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Veröffentlicht in:	Cell death & disease 2016-01, Vol.7 (1), p.e2060-e2060
Hauptverfasser:	Yuan, C-H, Filippova, M, Krstenansky, J L, Duerksen-Hughes, P J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/596/2560 631/80/82/23 631/80/86 692/699/67/1059/99 Antibodies Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - physiology Biochemistry Biomedical and Life Sciences Cancer Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - virology Cell Biology Cell Culture Cell Line Cell Line, Tumor Chemotherapy Cisplatin - administration & dosage Cisplatin - pharmacology Doxorubicin - administration & dosage Doxorubicin - pharmacology Drug Synergism Flavonoids - administration & dosage Flavonoids - pharmacology Flavonols - administration & dosage Flavonols - pharmacology Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - pathology Head and Neck Neoplasms - virology Human papillomavirus Humans Imidazoles - administration & dosage Imidazoles - pharmacology Immunology Life Sciences Oncogene Proteins, Viral - antagonists & inhibitors Oncogene Proteins, Viral - metabolism Original original-article Papillomaviridae - drug effects Papillomaviridae - metabolism Papillomavirus Infections - drug therapy Papillomavirus Infections - virology Pyridines - administration & dosage Pyridines - pharmacology Repressor Proteins - antagonists & inhibitors Repressor Proteins - metabolism Risk factors Signal transduction Squamous Cell Carcinoma of Head and Neck TNF-Related Apoptosis-Inducing Ligand - administration & dosage TNF-Related Apoptosis-Inducing Ligand - pharmacology
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