Cell Mediated Photothermal Therapy of Brain Tumors
Gold based nanoparticles with strong near infra-red (NIR) absorption are ideally suited for photothermal therapy (PTT) of brain tumors. The goal of PTT is to induce rapid heating in tumor tissues while minimizing thermal diffusion to normal brain. PTT efficacy is sensitively dependent on both nanopa...
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| Veröffentlicht in: | Journal of neuroimmune pharmacology 2017-03, Vol.12 (1), p.99-106 |
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| container_title | Journal of neuroimmune pharmacology |
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| creator | Hirschberg, Henry Madsen, Steen J. |
| description | Gold based nanoparticles with strong near infra-red (NIR) absorption are ideally suited for photothermal therapy (PTT) of brain tumors. The goal of PTT is to induce rapid heating in tumor tissues while minimizing thermal diffusion to normal brain. PTT efficacy is sensitively dependent on both nanoparticle concentration and distribution in tumor tissues. Nanoparticle delivery via passive approaches such as the enhanced permeability and retention (EPR) effect is unlikely to achieve sufficient nanoparticle concentrations throughout tumor volumes required for effective PTT. A simple approach for improving tumor biodsitribution of nanoparticles is the use of cellular delivery vehicles. Specifically, this review focuses on the use of monocytes/macrophages (Mo/Ma) as gold nanoparticle delivery vectors for PTT of brain tumors. Although the efficacy of this delivery approach has been demonstrated in both in vitro and animal PTT studies, its clinical potential for the treatment of brain tumors remains uncertain. |
| doi_str_mv | 10.1007/s11481-016-9690-9 |
| format | Article |
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The goal of PTT is to induce rapid heating in tumor tissues while minimizing thermal diffusion to normal brain. PTT efficacy is sensitively dependent on both nanoparticle concentration and distribution in tumor tissues. Nanoparticle delivery via passive approaches such as the enhanced permeability and retention (EPR) effect is unlikely to achieve sufficient nanoparticle concentrations throughout tumor volumes required for effective PTT. A simple approach for improving tumor biodsitribution of nanoparticles is the use of cellular delivery vehicles. Specifically, this review focuses on the use of monocytes/macrophages (Mo/Ma) as gold nanoparticle delivery vectors for PTT of brain tumors. Although the efficacy of this delivery approach has been demonstrated in both in vitro and animal PTT studies, its clinical potential for the treatment of brain tumors remains uncertain.</description><identifier>ISSN: 1557-1890</identifier><identifier>EISSN: 1557-1904</identifier><identifier>DOI: 10.1007/s11481-016-9690-9</identifier><identifier>PMID: 27289473</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Brain cancer ; Brain Neoplasms - metabolism ; Brain Neoplasms - therapy ; Cell Biology ; Gold - administration & dosage ; Gold - metabolism ; Humans ; Hyperthermia, Induced - methods ; Immunology ; Invited Review ; Macrophages - metabolism ; Metal Nanoparticles - administration & dosage ; Monocytes - metabolism ; Neurosciences ; Pharmacology/Toxicology ; Phototherapy - methods ; Tumors ; Virology</subject><ispartof>Journal of neuroimmune pharmacology, 2017-03, Vol.12 (1), p.99-106</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Journal of Neuroimmune Pharmacology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-1deea713a8a4fcf7833cf140ccf39ac02e97004c75c2e6d57a16f455a5c83d53</citedby><cites>FETCH-LOGICAL-c470t-1deea713a8a4fcf7833cf140ccf39ac02e97004c75c2e6d57a16f455a5c83d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11481-016-9690-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11481-016-9690-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27289473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirschberg, Henry</creatorcontrib><creatorcontrib>Madsen, Steen J.</creatorcontrib><title>Cell Mediated Photothermal Therapy of Brain Tumors</title><title>Journal of neuroimmune pharmacology</title><addtitle>J Neuroimmune Pharmacol</addtitle><addtitle>J Neuroimmune Pharmacol</addtitle><description>Gold based nanoparticles with strong near infra-red (NIR) absorption are ideally suited for photothermal therapy (PTT) of brain tumors. The goal of PTT is to induce rapid heating in tumor tissues while minimizing thermal diffusion to normal brain. PTT efficacy is sensitively dependent on both nanoparticle concentration and distribution in tumor tissues. Nanoparticle delivery via passive approaches such as the enhanced permeability and retention (EPR) effect is unlikely to achieve sufficient nanoparticle concentrations throughout tumor volumes required for effective PTT. A simple approach for improving tumor biodsitribution of nanoparticles is the use of cellular delivery vehicles. Specifically, this review focuses on the use of monocytes/macrophages (Mo/Ma) as gold nanoparticle delivery vectors for PTT of brain tumors. Although the efficacy of this delivery approach has been demonstrated in both in vitro and animal PTT studies, its clinical potential for the treatment of brain tumors remains uncertain.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - therapy</subject><subject>Cell Biology</subject><subject>Gold - administration & dosage</subject><subject>Gold - metabolism</subject><subject>Humans</subject><subject>Hyperthermia, Induced - methods</subject><subject>Immunology</subject><subject>Invited Review</subject><subject>Macrophages - metabolism</subject><subject>Metal Nanoparticles - administration & dosage</subject><subject>Monocytes - metabolism</subject><subject>Neurosciences</subject><subject>Pharmacology/Toxicology</subject><subject>Phototherapy - methods</subject><subject>Tumors</subject><subject>Virology</subject><issn>1557-1890</issn><issn>1557-1904</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kd1LwzAUxYMoTqd_gC9S8MWX6r1t0jQvgg6_YKIPew8xTbeOtplJK-y_N2MfTMGnG7i_e3IOh5ALhBsE4LcekeYYA2axyATE4oCcIGM8RgH0cPvOBQzIqfdzAEopwDEZJDzJBeXpCUlGpq6jN1NUqjNF9DGzne1mxjWqjiZhqsUysmX04FTVRpO-sc6fkaNS1d6cb-aQTJ4eJ6OXePz-_Dq6H8eacuhiLIxRHFOVK1rqkudpqkukoHWZCqUhMYIHR5oznZisYFxhVlLGFNN5WrB0SO7Wsov-szGFNm3nVC0XrmqUW0qrKvl701YzObXfkiEVlEEQuN4IOPvVG9_JpvI6xFWtsb2XmCcZBxYsBvTqDzq3vWtDOomCQcZpkAwUrintrPfOlDszCHJViFwXIkMhclWIFOHmcj_F7mLbQACSNeDDqp0at_f1v6o_rxOVmw</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Hirschberg, Henry</creator><creator>Madsen, Steen J.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170301</creationdate><title>Cell Mediated Photothermal Therapy of Brain Tumors</title><author>Hirschberg, Henry ; 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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Biomedical and Life Sciences Biomedicine Brain cancer Brain Neoplasms - metabolism Brain Neoplasms - therapy Cell Biology Gold - administration & dosage Gold - metabolism Humans Hyperthermia, Induced - methods Immunology Invited Review Macrophages - metabolism Metal Nanoparticles - administration & dosage Monocytes - metabolism Neurosciences Pharmacology/Toxicology Phototherapy - methods Tumors Virology |
| title | Cell Mediated Photothermal Therapy of Brain Tumors |
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